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Systems Biology approaches to understanding glutathione metabolism

Systems Biology approaches to understanding glutathione metabolism. Dr Najl Valeyev. Centre for Molecular Processing. University of Kent. Edinburgh. 29 September 2010 . Different types of Systems. Electronic circuits design. Weather. Stock market. Aircraft flight controllers.

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Systems Biology approaches to understanding glutathione metabolism

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  1. Systems Biology approaches to understanding glutathione metabolism Dr Najl Valeyev Centre for Molecular Processing University of Kent Edinburgh 29 September 2010

  2. Different types of Systems Electronic circuits design Weather Stock market Aircraft flight controllers

  3. Causative knockouts of “functional” parts Lazebnik Y, Cancer Cell. 2002 Sep;2(3):179-82

  4. Linking parts with “disease” phenotypes

  5. Family classification according to Phenotype

  6. Idealised Cell as a System

  7. The Complexity Problem ? ? ?

  8. Science or Art ?

  9. The Complexity Problem

  10. Major Modelling Principle

  11. Knowledge 1 Knowledge 2 True Object Knowledge 3 Knowledge 4

  12. Model 1 Model 2 True Object Model 3 Model 4

  13. Comparison of experiments with simulations Model predictions Experiments wt gshA- SpeA- gshA-SpeA-

  14. Stochastic interactions between models and experiments • to test and evaluate the structure of the assumed intracellular interactions with the pathways • to identify inconsistent hypotheses and design experiments to clarify the properties of signalling pathways • to provide advanced interpretation of the experimental data • to developed an integrative model of fimbriation should lead to deterministic conclusions

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