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Adolescents- Surgery. Adolescents- Controls. Adults- Surgery. Assessed for eligibility (n=100). Adults identified from the Swedish Obesity Surgery Register (SOReg) (n=81). Adolescents identified from the Swedish Childhood Obesity Treatment Register (BORIS) (n=81). Enrollment.

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Presentation Transcript
slide1

Adolescents-Surgery

Adolescents- Controls

Adults- Surgery

Assessed for eligibility (n=100)

Adults identified from the Swedish Obesity Surgery Register (SOReg)

(n=81)

Adolescents identified from the Swedish Childhood Obesity Treatment Register (BORIS) (n=81)

Enrollment

Excluded

(n =18)

Decline to participate

Allocated to intervention (n=82)

Allocation

Excluded (n =1)

Declines surgery

Surgical intervention: laparoscopic Roux-en-Y gastric bypass (n=81)

Intervention

Visit 1 yr (n=81)

(n=81)

(n=81)

Follow-Up

2 yr 1 yr

Visit 2 yr (n=81)

(n=59)

(n=81)

eFigure1: CONSORT flow chart of patients in study

slide2

Relative weight change:

Women

Men

15

15

Control, adolescents (AC)

Control, adolescents

AC

Gastric bypass, adolescents (GBA)

Gastric bypass, adolescents

GBA

10

10

Gastric bypass, adults

Gastric bypass, adults (GBC)

GBC

5

5

0

0

-

5

-

5

-

10

-

10

-

15

-

15

Relative weight change, %

-

20

-

20

-

25

-

25

-

30

-

30

-

35

-

35

-

40

-

40

0

1

2

0

1

2

Body mass index:

50

50

45

45

40

40

)

2

35

35

30

30

25

25

Body mass index (kg/m

20

20

15

15

10

10

5

5

AC

AC

GBA

GBA

0

0

GBC

GBC

0

1

2

0

1

2

Patients, n:

Follow

-

up, years

Follow

-

up, years

AC

46

46

31

35

35

28

GBA

53

53

53

28

28

28

GBC

53

53

53

28

28

28

eFigure 2 Relative weight changes and body mass index in adolescents and adults undergoing gastric

bypass surgery, split by gender

slide3

Insulin

Insulin

Insulin

Insulin

Glucose

Glucose

Glucose

Glucose

HbA1c

HbA1c

HbA1c

HbA1c

Lpk

Lpk

Lpk

Lpk

CRP

CRP

CRP

CRP

50

50

50

50

6

6

6

6

5

5

5

5

10

10

10

10

10

10

10

10

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

9

9

9

9

9

9

9

9

5

5

5

5

8

8

8

8

40

40

40

40

4

4

4

4

8

8

8

8

7

7

7

7

7

7

7

7

4

4

4

4

6

6

6

6

30

30

30

30

3

3

3

3

6

6

6

6

5

5

5

5

3

3

3

3

5

5

5

5

/l

/l

/l

/l

10*9/l

10*9/l

mg/l

mg/l

%

%

mU

mU

)

)

mmol

mmol

4

4

4

4

20

20

20

20

2

2

2

2

4

4

4

4

2

2

2

2

3

3

3

3

3

3

3

3

2

2

2

2

10

10

10

10

1

1

1

1

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

1

1

1

1

2

2

2

2

0

0

0

0

1

1

1

1

2

2

2

2

0

0

0

0

1

1

1

1

2

2

2

2

0

0

0

0

1

1

1

1

2

2

2

2

0

0

0

0

1

1

1

1

2

2

2

2

2

2.

2

0

0

3.

5

2.

0

140

140

90

90

Triglycerides

LDL

HDL

Systolic

Systolic

Systolic

Systolic

BP

Diastolic

Diastolic

Diastolic

Diastolic

BP

BP

BP

BP

80

80

80

80

80

80

3

3.

0

0

0

120

120

120

120

120

120

70

70

70

70

70

70

1

1.

5

5

1

1.

1

5

5

5

2.

2

2

5

5

5

100

100

100

100

100

100

60

60

60

60

60

60

2.

2

2

0

0

0

80

80

80

80

80

80

50

50

50

50

50

50

1

1

1.

0

0

0

1

0

·

40

40

40

40

40

40

mmHg

mmHg

1

1.

1

5

5

5

60

60

60

60

60

60

mmol/l

mmol/l

mmol/l

30

30

30

30

30

30

1

1

1.

0

0

0

40

40

40

40

40

40

0

0

0.

5

5

5

0.

0

0

5

5

5

20

20

20

20

20

20

0

0.

0

5

5

5

20

20

20

20

20

20

10

10

10

10

10

10

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

0

0.

0

0

0

0

0

0

0.

0

0

0

0.

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

0

0

0

0

0

0

1

1

1

1

1

1

2

2

2

2

2

2

0

0

0

0

0

0

1

1

1

1

1

1

2

2

2

2

2

2

0

0

0

0

0

0

1

1

1

1

1

1

2

2

2

2

2

2

0

0

0

0

0

0

1

1

1

1

1

1

2

2

2

2

2

2

0

0

0

0

0

0

1

1

1

1

1

1

2

2

2

2

2

2

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Follow

Follow

Follow

Follow

Follow

-up,

-up,

-up,

-up,

-up,

years

years

years

years

years

eFigure3 Biochemical and blood pressure data in adolescents after gastric bypass surgery, split by gender

slide4

eFigure 4 Quality of life data (SF-36) in adolescents after gastric bypass surgery, split by gender

Physical functioning (PF)

Role-physical (RP)

Bodily Pain (BP)

General Health (GH)

100

100

100

100

80

80

80

80

60

60

60

60

36 Score

-

Mean SF

40

40

40

40

20

20

20

20

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

0

0

0

0

0

1

2

0

1

2

0

1

2

0

1

2

Vitality (VT)

Social Functioning (SF)

Mental Health (MH)

Role Emotional (RE)

100

100

100

80

80

80

80

60

60

60

60

36 Score

-

Mean SF

40

40

40

40

20

20

20

20

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Boys

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

Girls

0

0

0

0

0

1

2

0

1

2

0

1

2

0

1

2

Follow

Follow

-

-

up, years

up, years

Follow

Follow

-

-

up, years

up, years