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This summary reviews key randomized controlled trials assessing the effectiveness of altered fractionation in conjunction with chemotherapy for patients with head and neck cancers. The article by Bernier (2005) explores how modifying radiation delivery, when combined with chemotherapy, can improve treatment outcomes, potentially offering a new frontier in oncological strategies for these malignancies. The findings highlight the promise of concurrent treatment modalities in enhancing therapeutic efficacy and patient survival rates.
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Table 1 Summary of the main randomized controlled trials of chemotherapy-enhanced radiation therapy-altered fractionation in head and neck cancer Bernier J (2005) Alteration of radiotherapy fractionation and concurrent chemotherapy: a new frontier in head and neck oncology? Nat Clin Pract Oncol 2 305–314 10.1038/ncponc0201