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Inflammation. What is it? What are the stages, and occurrences in those stages? Extensions?. Human Biology. Inflammation. Attempt to restore homeostasis in an area. Injury…the inflammatory response is initiated. Protective, defensive. Inflammation. Etiologies: Mechanical Trauma

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Inflammation

Inflammation

What is it?

What are the stages, and occurrences in those stages?

Extensions?

Human Biology


Inflammation1
Inflammation

  • Attempt to restore homeostasis in an area.

  • Injury…the inflammatory response is initiated. Protective, defensive.


Inflammation2
Inflammation

  • Etiologies:

    • Mechanical Trauma

      • MVC (collisions), Knife Wounds, Gunshots, Surgery, twisting an ankle, knee.

    • Foreign invaders (like bacteria)

      • Toxins. Entrance though skin breaks (burn, splinter, wounds)


Inflammation3
Inflammation

  • Symptoms

    • Erythema

      • Redness, heat

    • Pain

    • Edema (swelling)



Inflammation

Inflammation due to gout

http://www.whathealth.com/gout/picture-3.html




Inflammation

Lymphedema

Damaged, absent, malformed vessels

Note: This is showing you an illustration of edema, and not the entire inflammatory response.

http://meded.ucsd.edu/isp/1994/im-quiz/images/primedema.jpg


Inflammation has five basic stages
Inflammation has five basic stages:

Vasodilation

Phagocyte Migration

Nutrient/Metabolic Increase

Fibrin Formation

Pus Formation


Inflammatory stages
Inflammatory Stages

1) Vasodilation and increased permeability of blood vessels.

  • Histamine release does this at the site of damage. Pain from damages nerve endings.

    • Chemical released during allergy, inflammatory response.

  • Causes redness and swelling


Inflammatory stages1
Inflammatory Stages

2) Phagocyte migration

  • White Blood cells engulf and destroy bacteria and dead tissue.




Inflammatory stages2
Inflammatory Stages

3) Release of nutrients/Metabolic increase

  • Need more energy to fight infection/wounds.

  • Cellular respiration increase

Need more energy

To deal with this


Inflammation

Mechanically wounded epithelium forming

New junctions (arrow). (false color)

ls.berkeley.edu/bio/ gallery_mcb/wound.html


Inflammatory stages3
Inflammatory Stages

4) Fibrin Formation

  • Soluble protein called fibrinogen coverts to fibrin.

  • Traps bacteria at the site to isolate infected/damaged area.


Inflammation

http://www.chestpainperspectives.com/images/cpp_images/Fibrin.jpghttp://www.chestpainperspectives.com/images/cpp_images/Fibrin.jpg


Inflammatory stages4
Inflammatory Stageshttp://www.chestpainperspectives.com/images/cpp_images/Fibrin.jpg

5) Pus Formation

  • Thick fluid containing live cells, dead cells, bacteria, white blood cells.


Inflammation

192.107.108.56/.../ pictureglossary.htmhttp://www.chestpainperspectives.com/images/cpp_images/Fibrin.jpg


Inflammation

www.lhsc.on.ca/ wound/wounds.htmhttp://www.chestpainperspectives.com/images/cpp_images/Fibrin.jpg


Inflammation

http://www.larve.com/Images/images_legulcers/magots_small-cavity_wound.jpghttp://www.larve.com/Images/images_legulcers/magots_small-cavity_wound.jpg

Maggot Therapy


Do you doubt the effectiveness of this treatment
Do you doubt the effectiveness of this treatment??http://www.larve.com/Images/images_legulcers/magots_small-cavity_wound.jpg

  • The pictures you will see are proof that maggot therapy can help patients that have not responded to conventional therapy.


Inflammation

Gangrenous ulcerationshttp://www.larve.com/Images/images_legulcers/magots_small-cavity_wound.jpg

Patient was in hospital

for 5 weeks, receiving IV

antibiotics and surgery.

Doesn’t look too good.


Inflammation

Two weeks later, after maggots have been applied. See the healthy tissue? It is red and bloody, but healthy.


Inflammation

3 Months later… healthy tissue? It is red and bloody, but healthy.

An excellent result.

The scarring will fade

over the coming months.


Inflammation

Surgeons had a tough time figuring out which was good tissue and bad tissue, due to the advanced nature of the ulceration. They didn’t want to cut too much away.

3 years of foot ulcers in this 70 yr. old patient.


Inflammation

After maggots were applied, the wound was cleaned, and the dead tissue was removed. As you can tell, the maggots did a much better job than the surgeons could.


Inflammation

After healing, the wound looks fantastic. dead tissue was removed. As you can tell, the maggots did a much better job than the surgeons could.

Two years afterwards, the wound had not reoccurred.

www.ucihs.uci.edu/com/ pathology/sherman/cases.htm

Last 7 slides are from Maggot Therapy Project, University of California, Irvine.


Inflammation

  • http://www.youtube.com/watch?v=bAY7OKp6D7w dead tissue was removed. As you can tell, the maggots did a much better job than the surgeons could.

    http://www.youtube.com/watch?v=QYhQ1Nrpw_s&NR=1

  • http://www.youtube.com/watch?v=6Xt6NWkgydM