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Nuts and Bolts of Dysplasia in IBD

Objectives. What is dysplasia, and where does it come from?Natural history of dysplasiaHow do we find it, and what do we do about it?Prevention of dysplasia. Dysplasia. DysplasiaUnequivocally neoplastic transformationDysplasia in IBDMay be flat, difficult to detect at early stageMay be visibl

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Nuts and Bolts of Dysplasia in IBD

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    1. Nuts and Bolts of Dysplasia in IBD Tad Dryden, MD, MSPH Associate Professor of Medicine University of Louisville

    2. Objectives What is dysplasia, and where does it come from? Natural history of dysplasia How do we find it, and what do we do about it? Prevention of dysplasia

    3. Dysplasia Dysplasia Unequivocally neoplastic transformation Dysplasia in IBD May be flat, difficult to detect at early stage May be visible on endoscopy (elevated) Dysplasia in a non-IBD Polyp Even in the absence of IBD, every adenoma is dysplastic in normal people ALL ADENOMAS ARE DYSPLASTIC BY DEFINITION

    4. Why Do We Care?

    5. Cumulative Risk of CRC in UC 0.5-1.0% per year after 10 years of disease

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