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Vasopressin

Vasopressin

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Vasopressin

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  1. Vasopressin Gobind Gill

  2. Structure http://upload.wikimedia.org/wikipedia/commons/thumb/c/c6/Arginine_vasopressin3d.png/778px-Arginine_vasopressin3d.png

  3. Structure http://www.cancer-therapy.org/CT/v2/B/HTML/32.%20Gomez%20et%20al,%20279-290%20copy.html

  4. Background • Hypothalamus • Pituitary Gland • Stimulii • Functions • Water retention in kidney • Blood vessel constriction

  5. Regulation in Kidney http://vasopressin.files.wordpress.com/2011/09/neg-feedback2.jpg

  6. Regulation in Kidney http://vasopressin.files.wordpress.com/2011/09/neg-feedback3.jpg

  7. Site of Action in Kidney http://faculty.pasadena.edu/dkwon/chapter%2020/Chapter%2020_A_files/slide0056_image007.jpg

  8. Mechanism of Action http://faculty.pasadena.edu/dkwon/chapter%2020/Chapter%2020_A_files/slide0056_image008.jpg

  9. Mechanism of Action http://www.samsca.com/role-vasopressin.aspx

  10. Mechanism of action http://vasopressin.files.wordpress.com/2011/09/vasopressin-receptor.jpg

  11. Other Influencers

  12. Vasopressin-Related Disorders • Central diabetes insipidus • Thirst • Dehydration • Large volume of dilute urine • Treatment: desmopressin • Hyponatremia • Low blood osmolarity • Increased water retention • Side effects: headache, nausea vomiting, fatigue, loss of apetite • Treatment: VR2 agonist

  13. Questions