Vasopressin Antidiuretic hormone (ADH) Cameron Wolf
Vasopressin • Vasopressin, also known as arginine vasopressin, is produced in the posterior pituitary gland. • Within hypothalamic neurons the hormone is packed in secretory vesicles with a the carrier protein neurophysin. Both of these are released from the secretory vesicles upon hormone secretion
Target Cell of Vasopressin • Vasopressin primarily targets the Kidney • By increasing the water permeability and collecting duct cells in the kidney it allows us to retain more water and excretion of more concentrated urine.
When is it released? Typical amounts? • Vasopressin is released when the sensitive osmoreceptors in the hypothalamus detect very small increases in extracellular fluid osmolality • Typical amounts of vasopressin range from 1 to 5 pg/mL (picograms per milliliter)
What does ADH do for the Body? • Vasopressin helps the body maintain water levels. It also helps keep the concentration of urine and blood in check.
Too Little? • Hypothalamic diabetes insipidus- in inadequate fluids are consumed, the large amount of water lost in the urnie may cause dehydration and high sodium levels in the blood
Too Much? • Nephrogenic diabetes insipidus (NDI) - a defect in the small tubes in the kidneys causes a person to pass a large amount of urine • This disease occurs when the kidney tubules do not respond to ADH-the kidneys release an excessive amount of water into the urnie, producing a large quantity of very dilute urine.
How is NDI treated? • They need to consume enough fluids to equal the amount of urine produced. • Low-salt and low-protein diet