A Strategy to Reduce Cardiovascular Disease by More Than 80% . BMJ 2003;326:1419 (28 June). Why This Paper ?. Pre operative Operative Post Operative. Why This Paper ?. CABG patients only - Majority of our work Majority have BP, Chol, Platelet, poor LV and Homocysteine problems
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BMJ 2003;326:1419 (28 June)
Pre operative Operative Post Operative
Relative Risks (95% Confidence Intervals) of ischaemic Heart Disease Events and All Strokes (Fatal and Non-fatal) in 15 Randomised Trials of Low Dose Aspirin
Absolute reductions* (mmol/l) (with 95% confidence intervals) and percentage reductions in serum LDL cholesterol concentration according to statin and daily dose (summary estimates from 164 randomised placebo controlled trials)
Relative distributions of risk factors in men who subsequently died of ischaemic heart disease or stroke and in men who did not. Gaussian distribution fitted to data from a cohort of 22 000 men followed prospectively for 10 years
The combination (Polypill) reduces IHD events by 88% (95% confidenceinterval 84% to 91%) and stroke by 80% (71% to 87%).
One thirdof people taking this pill from age 55 would benefit, gainingon average about 11 years of life free from an IHD event orstroke.
Summing the adverse effects of the components observedin randomised trials shows that the Polypill would cause symptomsin 8-15% of people (depending on the precise formulation).