1 / 11

Aldehydes and Ketones

Aldehydes and Ketones. Nucleophilic Addition to the Carbonyl Group. A. Aldehyde 1. Oxidation of primary alcohols. PDC: Pyridinium Chlorochromate C5H5NHCrO3Cl. 2. Reduction of acid chloride. 3. Oxidation of methylaromatics.  Aromatic aldehydes only!. K 2 Cr 2 O 7 , special cond.

niveditha
Download Presentation

Aldehydes and Ketones

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Aldehydes and Ketones Nucleophilic Addition to the Carbonyl Group

  2. A. Aldehyde 1. Oxidation of primary alcohols PDC: Pyridinium Chlorochromate C5H5NHCrO3Cl

  3. 2. Reduction of acid chloride 3. Oxidation of methylaromatics Aromatic aldehydes only!

  4. K2Cr2O7, special cond. or C5H5NHCrO3Cl 1o alcohol Ar-CH3 Aromatic only 1. CrO3 /(AcO)2O 2. H2O/H+ aldehyde acid chloride LiAlH(O-t-Bu)3

  5. B. Ketone 1. Oxidation of secondary alcohols 2. Friedel-Crafts acylation Aromatic ketones (phenones) only

  6. 3. Coupling of RCOCl and R2CuLi

  7. 2o alcohol K2Cr2O7, etc. ketone acid chloride + ArH AlCl3 acid chloride + R2CuLi

More Related