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Obsessive-Compulsive Disorder. Thien-An Le. Obsessive-Compulsive Disorder and Related Disorders. Obsessive-Compulsive Disorder Body Dysmorphic Disorder Hoarding Disorder Trichotillomania Excoriation Disorder Substance/Medication-Induced Obsessive-Compulsive and Related Disorder

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obsessive compulsive disorder and related disorders
Obsessive-Compulsive Disorder and Related Disorders
  • Obsessive-Compulsive Disorder
  • Body Dysmorphic Disorder
  • Hoarding Disorder
  • Trichotillomania
  • Excoriation Disorder
  • Substance/Medication-Induced Obsessive-Compulsive and Related Disorder
  • Obsessive-Compulsive and Related Disorder Due to Another Medical Condition
  • Other Specified Obsessive-Compulsive and Related Disorder
  • Unspecified Obsessive-Compulsive and Related Disorder
  • All characterized by preoccupations and by repetitive behaviors or mental acts in response to the preoccupations.
dsm v review diagnostic criteria
DSM-V Review: Diagnostic Criteria
  • A) Presence of obsessions, compulsions, or both:
    • Obsessions:
      • Recurrent and persistent thoughts, urges, or images that are experienced, as intrusive and unwanted, and cause marked anxiety or distress.
      • The individual attempts to ignore or suppress such thoughts, urges, or images, or to neutralize them with some other thought or action
      • Not pleasurable or voluntary
    • Compulsions:
      • Repetitivebehaviors or mental acts that the individual feels driven to perform in response to an obsession or according to rules that must be applied rigidly.
      • The behaviors or mental acts are aimed at preventing or reducing anxiety or distress, or preventing some dreaded event or situation
        • Not connected in a realistic way with what they are designed to neutralize or prevent, or are clearly excessive.
dsm v review diagnostic criteria1
DSM-V Review: Diagnostic Criteria
  • B) The obsessions or compulsions are time-consuming or cause clinically significant distress or impairment in social, occupational, or other important areas of functioning.
  • C) The obsessive-compulsive symptoms are not attributable to the physiological effects of a substance or another medical condition.
  • D) Not better explained by the symptoms of another mental disorder. 
  • Specify if:
    • With good or fair insight
    • With poor insight
    • With absent insight/delusional beliefs
    • Tic-related
dsm v diagnostic criteria examples
DSM-V: Diagnostic Criteria Examples
  • Persistent thoughts of contamination
  • Ruminations
  • Images of violent or horrific scenes
  • Urges to stab someone
  • Ritualizing
  • Washing
  • Checking
  • Counting
  • Repeating words silently
  • Hoarding

Obsessions

Compulsions

dsm v review diagnostic criteria themes
DSM-V Review: Diagnostic CriteriaThemes
  • Including:
    • Cleaning
      • contamination obsessions and cleaning compulsions
    • Symmetry
      • Symmetry obsessions and repeating, ordering, and counting compulsions
    • Forbidden or taboo thoughts
      • Aggressive, sexual, or religious obsessions and related compulsions and
    • Harm
      • Fears of harm to oneself or others and checking compulsions
  • Occur across different cultures
  • Relatively consistent over time in adults with the disorder
  • May be associated with different neural substrates
dsm v review diagnostic issues
DSM-V Review: Diagnostic Issues
  • Culture-Related Diagnostic Issues:
    • OCD occurs across the world.
    • Similarity across cultures in the gender distribution, age at onset, and comorbidity(Lewis-Fernández et al. 2010).
    • Similar symptom structure involving cleaning, symmetry, hoarding, taboo thoughts, or fear of harm(Bloch et al. 2008).
    • Regional variation in symptom expression
    • Cultural factors may shape the content of obsessions and compulsions.
  • Gender-Related Diagnostic Issues:
    • Males have an earlier age at onset & are more likely to have comorbidtic disorders.
    • Females more likely to have symptoms in the cleaning dimension
    • Males more likely to have symptoms in the forbidden thoughts and symmetry dimensions.
    • Onset or exacerbation of OCD & symptoms that can interfere with the mother-infantrelationship
dsm v associated and secondary features
DSM-V: Associated and Secondary Features
  • Cleaning
  • Symmetry
  • Taboo thoughts
  • Harming self or others
  • Hoarding
  • Increased suicide risks
  • Panic attacks
  • Agoraphobia
  • Distress
  • Avoid:
    • people,
    • places, and
    • things that trigger obsessions and compulsions
dsm v prevalence
DSM-V: Prevalence
  • United States: 1.2%
  • Internationally: 1.1%–1.8%
  • Females are affected at a slightly higher rate than males in adulthood,
  • Males are more commonly affected in childhood (Ruscio et al., 2010; Weissman et al., 1994)
dsm v onset
DSM-V: Onset
  • United States, mean onset: 19.5 years
    • 25% start by age 14 years (Kessler et al. 2005; Ruscio et al. 2010)
  • Onset after age 35 years is unusual
  • Males have an earlier age at onset than females
    • nearly 25% of males have onset before age 10 years (Ruscio et al. 2010).
  • Onset of symptoms is typically gradual.
    • Acute onset has also been reported.
dsm v course
DSM-V: Course
  • Usually chronic
    • Often with waxing and waning symptoms (Ravizza et al., 1997; Skoog & Skoog 1999)
    • Onset in childhood or adolescence can lead to a lifetime OCD
    • 40% of individuals with onset of OCD in childhood or adolescence may experience remission by early adulthood (Stewart et al. 2004)
  • Pattern of symptoms in adults can be stable over time, but it is more variable in children (Mataix-Cols et al. 2002; Swedo et al. 1989).
  • May be based on developmental stage
dsm v risk and prognostic features temperamental
DSM-V: Risk and Prognostic FeaturesTemperamental
  • Greater internalizing symptoms
  • Higher negative emotionality, and
  • Behavioral inhibition in childhood
    • (Coles et al. 2006; Grisham et al. 2011).
dsm v risk and prognostic features environmental
DSM-V: Risk and Prognostic FeaturesEnvironmental
  • Physical and sexual abuse and other stressful or traumatic events (Grisham et al., 2011)
  • Sudden onset of symptoms associated with different environmental factors
    • Infectious agents and a post-infectious autoimmune syndrome (Singer et al., 2012; Swedo et al., 2004).
dsm v risk and prognostic features genetic and physiological
DSM-V: Risk and Prognostic FeaturesGenetic and physiological
  • Rate of OCD among first-degree relatives of adults with OCD is approximately two times that among first-degree relatives of those without the disorder
  • Among first-degree relatives  increased 10-fold onset (Pauls 2010)
  • Familial transmission
    • 0.57 for monozygotic
    • 0.22 for dizygotic (Pauls 2010)
  • Dysfunction
    • Orbitofrontal cortex,
    • Anterior cingulate cortex, and
    • Striatum (Millad and Rauch 2012).
dsm v comorbidity
DSM-V: Comorbidity
  • Anxiety disorder: 76%
  • Depressive or bipolar disorder: 63%
  • Major depressive disorder: 41%
  • Obsessive-compulsive personality disorder:23%-32%
  • Body dysmorphic disorder
  • Trichotillomania
  • Excoriation disorder
  • ODD
  • Tic Disorder
components of ocd
Components of OCD

As per extant literature

diagnostic criteria
Diagnostic Criteria:
  • Presence of distressing intrusive, unwanted, thoughts, impulses, fears or images (obsessions), and/or repetitive behaviors or mental rituals (compulsions)
  • Knowledge that the thoughts and actions are senseless and unreasonable (Turner et al., 1985)
  • Rituals usually serve an anxiety-reducing function (Turner et al., 1985)
diagnostic criteria1
Diagnostic Criteria
  • Fear of germs
  • Fear of harm befalling self or others
  • Need for order or symmetry
  • Washing
  • Cleaning
  • Checking
  • Counting
  • Repeating
  • Touching
  • Straightening

Obsessions

Compulsions

(March et al., 2004)

diagnostic criteria 4 symptom dimensions
Diagnostic Criteria:4 Symptom Dimensions
  • Cleaning and contamination
    • Checking
  • Hoarding
  • Symmetry and ordering
    • Repeating and counting
  • Sexual and religious obsessions
    • Aggression, somatic issues, and checking
diagnostic criteria symptom prevalence
Diagnostic Criteria:Symptom Prevalence

(Mataix-Cols et al., 2008)

diagnosing in children
Diagnosing in Children
  • Must occur before puberty
  • Difficult to diagnose in children
    • Lack insight to realize obsessions are irrational (Kalra et al., 2009)
    • Prognosis is worse for children with poor insight
    • Lack of insight militates against the benefits of cognitive-behavioral therapy (CBT)
  • 40% of children deny compulsions are driven by obsessive thoughts
ocd differences in children
OCD Differences in Children
  • Symptom presentation
    • Change of obsessions/compulsions over time (Weiss, 2008)
    • Obsessions/compulsions vague, magical, or superstitious (Franklin, 2004)
    • Children have trouble describing their obsessions (Weis, 2008)
    • Fear that stating obsessions aloud will make them come true (Weis, 2008)
    • More likely to have tic-like compulsions
  • Patterns of comorbidity
    • ADHD
    • Tics: 2/3 children
      • Boys more likely to have comorbid
    • Tourette’s syndrome: 20-80%
      • Compulsions may be less severe
  • Sex distribution
    • Boys more likely: 2-3:1
    • At or after puberty: 1:1.35 (m:f)
  • Degree insight
  • Etiopathogenesis
diagnostic onset and course
Diagnostic Onset and Course
  • 1%-4% of children and adolescents
  • At least1/3 of adult OCD subjects had the onset of symptoms in childhood (Rasmussen & Eisen, 1992).
  • Children and adolescents share similar features with the exception of age at onset and OCD symptom expression. (Mancebo, 2008)
  • Consistent across lifespan (Stewart, 2007)
diagnostic onset and course eocd
Diagnostic Onset and Course:EOCD
  • Adult patients with EOCD were characterized by
    • (1) male gender predominance,
    • (2) greater number of clinically significant obsessions and compulsions,
    • (3) higher frequency of rituals repetition,
    • (4) an increased severity of obsessive–compulsive symptoms at baseline, and
    • (5) greater number of required therapeutic trials during the follow-up
diagnostic onset eocd v s locd
Diagnostic Onset:EOCD v.s LOCD
  • EOCD:
    • More premature onset.
    • More aggressive course.
    • More obsessions and compulsions.
    • May represent a more severe variety of the disorder.
    • Higher frequency of tic-like compulsions.
    • Higher frequency sensory phenomena .
    • Higher frequency comorbid tic disorders.
    • Worse short-term therapeutic response to SSRIs.
prevalence
Prevalence
  • Lifetime prevalence :1%-3% (Pauls, 2010)
  • Juveniles more likely to be males
  • Males: earlier onset (Mancebo, 2008)
    • At puberty, the sex ratio of affected individuals switches from pre- dominantly males to predominantly females (Kalra et al., 2009)
associated secondary features
Associated & Secondary Features
  • Higher suicide attempts
  • Depression
  • Anxiety
  • Celibacy rates:72% (Coryell, 1981)
    • Especially in men
    • Proportional to severity of the illness.
  • Marry later (Turner & Michelson, 1984).
  • Lower rates of fertility (Turner & Michelson, 1984)
  • Higher parental stress (Coles et al., 2006)
  • Interference in school, social, work, and family (Piacentini & Bergman, 2000)
    • Doing assigned chores at home: 61%
    • Getting ready for bed: 56%
    • Concentrating at school: 62%
    • Getting along with parents: 56%
    • Getting along with siblings: 53%
comorbidity
Comorbidity
  • Tic Disorder: 26%
  • Anxiety Disorder
  • Tourette’s disorder:18-25%
  • ADHD: 34-51%
  • Major depression: 33-39%
  • ODD: 17-51%
  • Overanxious disorder: 16%
  • Specific development: 24%
  • Simple phobias: 17%
  • Adjustment disorder w/depressed mood: 13%
  • CD: 7%
  • Separation anxiety: 7%
  • Enuresis: 4%
  • Juveniles: lower rates of mood, substance use and eating disorders compared to adults.
risk and prognostic features environmental factors
Risk and Prognostic Features Environmental Factors
  • 45% variance for younger sample (Hudziak et al., 2004)
  • Prenatal (Santangeloet al., 1994):
    • Labor complications
    • Maternal smoking
    • Excessive caffeine or alcohol
    • Difficulty getting pregnant: 53% (Vasconcelos et al., 2007)
    • Preexisting medical problems: 51% (Vasconcelos et al., 2007)
  • Parenting style (Albano, 2004)
    • Over controlling parents
    • Low parental acceptance
  • Aversive reaction to change (Zohar & Felz, 2001)
    • child tries to enforce consistency on objects and significant others
  • Family Size(Guerrero et al. ,2003)
  • Substance abuse ( Fontenelle& Hasler, 2007)
risk and prognostic features temperament
Risk and Prognostic Features Temperament
  • Behavioral Inhibition
    • Over- protective parenting (Coles et al., 2006)
    • Significantly predicted levels of OCD (Coles et al., 2006)
    • High levels of restraint, withdrawal, and avoidance of novel stimuli, of both a social and nonsocial nature (Garcia-Collet al., 1984)
  • Higher internalizing problems(Zohar & Felz, 2001)
    • More Shy
    • More emotional
    • More fearful
risk and prognostic features genetic factors
Risk and Prognostic Features Genetic Factors
  • Twin studies
    • Bolton et al., 2007:
      • 57% variance in MZ twins
      • 22% in DZ twins
    • Van Grootheest et al., 2005:
      • 45-65% genetic influences
  • Ritual repetition may represent a behavioral marker for a specific genotype.
  • 10-25% youths have at least 1 parent w/OCD
risk and prognostic features neurochemical factors
Risk and Prognostic Features Neurochemical Factors
  • Serotonergic systems
    • Central role
    • Only discovered by administering treatment and observing effects
  • Dopaminergic systems
    • Reported by adult patients w/ basal ganglia disorders
    • OCD, TS, Sydenham Chorea, Huntingon Chorea
  • Glutamatergic system
    • Primary excitatory neurotransmitter
    • Key role in the functioning of the fronto-striato-thalamo-cortical circuit (CSTC Circuit)
risk and prognostic features neuroimmune dysfunction
Risk and Prognostic Features Neuroimmune Dysfunction
  • Can be triggered by infections
    • Group A β-hemolytic streptococci (GABHS) are the most studied initial autoimmune response–inciting event
    • Viruses
    • Mycoplasma pneumonia
    • Borreliaburgdorferi
    • Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections—PANDAS
  • Parallels between:
    • Sydenham chorea,
    • Neurological manifestation of rheumatic fever, and childhood-onset OCD
  • Dysfunction in orbitofrontal-striatal circuit
    • Involved in the mediation of emotional responses to biologically significant stimuli
risk and prognostic features neurobiological substrates
Risk and Prognostic Features Neurobiological Substrates
    • Fronto-striato-thalamo-cortical circuit
      • Explains behavioral loop
  • fMRI studies:
    • Global and local deviant topological properties
      • Disturbances in brain network balance
      • Reduced small world efficacy @ baseline
      • Changes in modular structure
      • Basis of the inability to disengage from reverberating internal stimuli (Shin et al., 2013)
    • Reduced volume:
      • Left putamen (Hoexteret al., 2012)
      • Left medial orbitofrontal cortex (Hoexter et al., 2012)
      • Right medial orbitofrontal cortex (Hoexter et al., 2012)
      • Right anterior cingulate cortex (Hoexter et al., 2012)
      • Caudate (Saxena et al., 1999)
      • Thalamus(Saxena et al., 1999)
slide39

Risk and Prognostic Features Neurobiological Substrates: cortico-striato-thalamo-cortical circuit

dysfunction

  • Increased glutamatergic signals from the frontal cortex increaseexcitation in the striatum
  • increases inhibitory GABA signals to the GPi and SNr
      • Decreasesinhibitory output via GABA from Gpi and SNr to thalamus thalamic excitatory glutamatergic output to the frontal cortex.
      • External loop composed of the GPe and subthalamic nucleus (STN) is postulated to contribute to a steady state of excitation/inhibition

Glutamate

Glutamate Excitation

Inhibition GABA

Inhibition

slide40
Risk and Prognostic Features Neurobiological Substrates: cortico-striato-thalamo-cortical circuit dysfunction
  • Increased glutamatergic signals from the frontal cortex increaseexcitation in the striatum
  • increases inhibitory GABA signals to the GPi and SNr
      • unknown dysfunction at the striatum and GPe.
      • Decreased inhibition on the GPe leads to increased inhibition of the STN,
      • decreases its excitation of the GPi/SNr
      • GPi/SNr then decreases its inhibitory output on the thalamus, resulting in excitatory output to the frontal cortex
current models of ocd
Current Models of OCD
  • Belief and Appraisal Model (Beck, 1976)
    • Obsessions & compulsions are from specific sorts of dysfunctional beliefs.
    • Strength of belief influences insight to OCD.
  • Salkovskis’s Model (Salkovskis, 1985)
    • Most people experience intrusions/normal obsessions.
    • “Idea generator”
    • Individual appraises the intrusions Obsession
    • Compulsions are efforts to remove the intrusions and to prevent perceived harm.
literature based model1
Literature Based Model

More excitatory glutamatergic output

Reward Processing

Excitatory Glutamate output

INCR inhibition GABA

Reinforces compulsion due to escape/avoidance

Error Processing

Rumination of Obsessions

DECR inhibitory output

Prompts Action Compulsion

Anxiety

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