the neurobiology of deliberate self injury
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The Neurobiology of Deliberate Self-Injury. Sarah Swannell BSocSc(Hons)Psych Senior Research Technician Discipline of Psychiatry The University of Queensland. What is deliberate self-injury?.

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the neurobiology of deliberate self injury

The Neurobiology of Deliberate Self-Injury

Sarah SwannellBSocSc(Hons)Psych

Senior Research Technician

Discipline of Psychiatry

The University of Queensland

what is deliberate self injury
What is deliberate self-injury?
  • Deliberate destruction or alteration of body tissue without suicidal intent (Favazza, 1989) & done to relieve an undesirable emotional or psychological state
  • Low lethality & low intent to die
  • Repetitive
  • Borderline Personality Disorder
  • PTSD, depression, bi-polar disorder, schizophrenia, antisocial personality disorder
prevalence
Prevalence
  • 60% of psychiatric patients
  • 40% of high school students and university students
why do people self injure
Why do people self-injure?
  • to feel better
    • release tension
    • stop dissociating
    • turning emotional pain into physical pain which is easier to handle
    • avoiding suicide
but how does self injury make some people feel better
but how does self-injury make some people feel better?
  • what happens in the brain when people self-injure?
the 5 phases of self injury
The 5phases of self-injury
  • Perception of threat  unwanted negative emotion (desire to terminate it)
  • Choice of coping technique
  • Self-injury
  • Unknown mechanism of action
  • Objective and subjective tension relief
phase 1 perception of threat
PHASE 1. Perception of Threat

Immediate reaction

Sensory cortex  amygdala hypothalamus pituitary gland  adrenal gland

Delayed reaction

Sensory cortex  amygdala prefrontal cortex

Unwanted negative emotion

vulnerabilities to experiencing unwanted negative emotion
Vulnerabilities to experiencing unwanted negative emotion
  • more intense negative emotions
  • longer lasting negative emotions
  • BPD & PTSD studies
    • the Hypothalamic-Pituitary-Adrenal Axis (HPA) axis is more sensitive (Yehuda et al., 2001)
    • History of trauma
phase 2 choice of coping technique
PHASE 2. Choice of coping technique

Serotonin system

Prefrontal cortex-limbic system connection

Prior learning

Beliefs

serotonin system
Serotonin System
  • Impulsivity & aggression
    • Low levels of 5-HIAA in CSF of depressed suicide attempters (Asberg et al., 1976)
    • Reduced levels of 5-HIAA in male borderlines (Brown et al., 1982)
    • Low serotonin correlated with suicide attempts, assaultiveness, instability, aggression & impulsiveness (Coccaro et al., 1989; Markowitz et al., 1995)
    • Self-mutilators had more personality pathology, greater lifetime aggression, more antisocial behaviour, and lower levels of serotonin activity (Simeon et al., 1992)
slide11
Post-mortem studies of suicides found fewer presynaptic serotonin transporter sites in ventromedial prefrontal cortex, hypothalamus, occipital lobe, brainstem(Mann, 1998)
  • Peer-reared monkeys have lower serotonergic activity in comparison to maternally raised monkeys (Higley et al., 1993)
  • Adverse rearing sets serotonergic functioning at a lower level (Mann, 2003)
prefrontal cortex limbic system connection
Prefrontal cortex-limbic system connection
  • Emotion dysregulation via: dysfunctional transmission between prefrontal cortex and limbic system (amygdala/anterior cingulate are under inhibitory control of the prefrontal cortex)
    • dorsolateral prefrontal cortex (PFC) is implicated in effortful regulation of affect
    • the orbitofrontal cortex, middle temporal gyrus, cingulate cortex, and the caudate nucleus are implicated in the identification and production of affect (Ramel, 2005).
  • The ventromedial prefrontal cortex has been widely implicated in impulse regulation (Potenza, Leung, Blumberg, Peterson, Fulbright, Lacadie, Skudlarski & Gore, 2003; Fukui, Murai, Fukuyama, Hayashi,& Hanakawa, 2005).
prior learning
Prior Learning
  • Observation, accident
  • Lack of physical pain

Beliefs

  • Action is needed to reduce unpleasant feelings
  • Self-injury is acceptable
  • My body and self is disgusting and deserving of punishment
  • Overt action is needed to communicate feelings to others
  • I must control my body and myself
phase 3 self injury
PHASE 3. Self-injury
  • Noxious stimuli depolarize nociceptors & signals  dorsal root ganglia  dorsal horns in spinal cord
    • a) projection neurons  sensory info to brain
    • b) local excitatory & inhibitory interneurons  to brain & regulate flow of info to brain
  • Noxious stimuli travel up the spinal cord via anterolateral pathways and transmitted contralaterally to the brain.
  • Chemical signals arrive at thalamus, periaqueductal grey matter, primary sensory cortex and associated cortices, reticular formation, medulla, pons, midbrain, hypothalamus, and caudal anterior cingulate cortex (Ploghaus et al., 1999).
  • normally this results in subjective pain
endogenous opioid system
Endogenous opioid system
  • Approx 60% feel no pain(Bohus et al., 2000; Russ et al., 1993)
  • Abuse/neglect/trauma can alter EOS & reduce sensitivity to pain (Kirmayer et al., 1987; van der Kolk, 1989; Dubo et al., 1997; van der Kolk et al., 1991)
  • Decrease in pain sensitivity following early traumatic experiences has been reported in both animal and human studies (Russ et al., 1993)
slide16
In sample of BPD cutters, highest opioid levels correlated with recency and severity of cutting (Coid et al., 1983)
  • Plasma opioid levels were higher in BPD patients who had SIB without pain compared to normals (Simeon et al., 2001).
phase 5 tension relief
PHASE 5. Tension relief
  • Objective (psychophysiological measures) & subjective tension relief (Haines et al., 1995; Brain et al., 1998)
    • personalised imagery script
    • Finger pulse amplitude (FPA), electrocardiograph (ECG), heart rate (HR), respiration (RESP)
    • skin conductance level (SCL)
implications for clinicians
Implications for clinicians
  • Something is going on in the brain when people self-injure
  • Understand your clients
  • Work within your client’s limitations
  • Improve resilience, coping skills
  • Reduce stress
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