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RANK mediates tumor-infiltrating regulatory T-cell stimulation of mammary cancer metastasis

This study delves into how the RANK signaling pathway influences tumor-infiltrating regulatory T-cells, affecting the metastasis of mammary cancer. It discusses the role of preosteoclast and osteoclast cell differentiation in bone metastases, focusing on the impact of RANK, RANKL, IKKa, IKKa-P, and MASPIN. Moreover, the research explores cell migration, proliferation, and the development of pulmonary metastases in breast carcinoma cells due to factors like CD4+, CD25+, FOXP3, CCR1, and CCL5. The interactions between these elements shed light on the mechanisms underlying cancer progression.

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RANK mediates tumor-infiltrating regulatory T-cell stimulation of mammary cancer metastasis

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  1. RANK mediates tumor-infiltrating regulatory T-cell stimulationof mammary cancer metastasis Osteoscoop - Issue N°189 - June 2011

  2. Preosteoclast Osteoclast Cell differentiation Bonemetastases RANK RANKL

  3. Preosteoclast Osteoclast Cell differentiation Bonemetastases RANK RANKL RANK IKKa IKKa-P Cell migration and proliferation MASPIN Breast carcinoma cell Pulmonary metastases

  4. Tumor infiltrating T lymphocyte Preosteoclast Osteoclast CD4+ CD25+ Bonemetastases Cell differentiation RANK FOXP3 RANKL CCR1 RANK IKKa CCL5 IKKa-P Cell migration and proliferation MASPIN Breast carcinoma cell Pulmonary metastases

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