total synthesises of atrop abyssomicin c n.
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Total Synthesises of ( atrop -) Abyssomicin C. Pusheng Wang 2012/05/12. Contents. 1. Introduction 2. Sorensen’s Total Synthesis 3. Nicolaou’s Total Synthesis 4. Saicic’s Total Synthesis. 1. Introduction.

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contents
Contents
  • 1. Introduction
  • 2. Sorensen’s Total Synthesis
  • 3. Nicolaou’s Total Synthesis
  • 4. Saicic’s Total Synthesis
1 introduction
1. Introduction
  • Natural polycyclic polyketides isolated from the bottom (depth 289 m) of the Japanease Sea, as secondary metabolites(次级代谢产物) of the Gram-positive(革兰氏阳性)actinomycete(放线菌).
  • Antibiotic activity against Gram-positive bacteria
2 sorensen s total synthesis
2. Sorensen’s Total Synthesis

Retrosynthetic analysis

E. J. Sorensen, Angew. Chem. Int. Ed. 2005, 44, 6533 – 6537.

3 nicolaou s total synthesis
3. Nicolaou’sTotal Synthesis

Retrosynthetic analysis

K. C. Nicolaou,Angew. Chem. Int. Ed. 2006, 45, 3256 – 3260.

4 saicic s total synthesis
4. Saicic’sTotal Synthesis

Retrosynthetic analysis

Radomir N. Saicic, Angew. Chem. Int. Ed. 2012, 51, 1 – 6.