DA Transporter Currents: A Reason for Excitement. Susan L. Ingram WSU-Vancouver, Vancouver WA. Neurotransmitter transporters: Transport is electrogenic. Neurotransmitter. DA, 5HT, NE, GABA, Glycine . +. 1. -. 3 Na. -. 1Cl. Substrate-gated uncoupled conductance. cytoplasm.
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Susan L. Ingram
WSU-Vancouver, Vancouver WA
DA, 5HT, NE, GABA, Glycine
biocytinWhole-cell patch clamp recordings from DA neurons in culture
pNO3/pCl = 14
* Permeability to nitrate is 10-fold greater than
GABAA-mediated chloride conductance (pNO3/pCl = 2.5)
* Shi, et al. (2000) Dual effects of amphetamine on dopamine neurons mediated by
dopamine and nondopamine receptors. J Neurosci 20(9):3504-3511.
DA - control
GABAA-mediated chloride conductance is inhibitory
* Gramicidin perforated-patch recordings
DAT-mediated chloride conductance is excitatory
to stimulate neurotransmitter release?