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Introduction to Stem Cells. What is a stem cell?. Master cell. Undifferentiated (unspecialised cell type). Found in all multicellular organisms. Self-renewing and can differentiate. Can you give examples of differentiated cells and their functions?. Embryonic stem cells. Totipotent:

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what is a stem cell
What is a stem cell?

Master cell.

Undifferentiated (unspecialised cell type).

Found in all multicellular organisms.

Self-renewing and can differentiate.

Can you give examples of differentiated cells and their functions?

embryonic stem cells
Embryonic stem cells

Totipotent:

toti = total

potent = capacity

The state of the cells after the first few divisions of the fertilised egg.

Have the capacity to become all cell types plus placenta.

embryonic stem cells4
Embryonic stem cells

Pluripotent:

pluri = many

potent = capacity

At blastocyst stage cells become pluripotent.

Have the capacity to become all cell types but not placenta.

Cells of most interest to research scientists.

adult stem cells
Adult stem cells

Multipotent

Can develop into cells that are closely related.

Limited number of several cell types.

Make all cell types from the tissue they come from.

Found in many parts of the body.

Can self-renew over a lifetime.

focus questions
Focus questions

What is the unique property of stem cells which makes them different from a specialised cell?

focus questions7
Focusquestions

What does it mean when we say a cell has become ‘differentiated’?

focus questions8
Focusquestions

Embryonic stem cells are described as pluripotent whereas adult stem cells are multipotent. Describe in your own words what these terms mean.

focus questions9
Focus questions

Why does adult tissue need stem cells?

focus questions10
Focus questions

Why are research scientists so interested in using stem cells?

focus questions11
Focus questions

We have discussed several types of stem cells. Which type do you think would be most useful to treat human disease? Give a reason for your answer.

focus questions12
Focus questions

Each group has to investigate a disease that could be treated with stem cells. For the disease the group has identified:

describe the condition

identify the organ/system affected

give a reason for why stem cells rather

than drug therapy would be beneficial.