Introduction to Stem Cells. What is a stem cell?. Master cell. Undifferentiated (unspecialised cell type). Found in all multicellular organisms. Self-renewing and can differentiate. Can you give examples of differentiated cells and their functions?. Embryonic stem cells. Totipotent:
Undifferentiated (unspecialised cell type).
Found in all multicellular organisms.
Self-renewing and can differentiate.
Can you give examples of differentiated cells and their functions?
toti = total
potent = capacity
The state of the cells after the first few divisions of the fertilised egg.
Have the capacity to become all cell types plus placenta.
pluri = many
potent = capacity
At blastocyst stage cells become pluripotent.
Have the capacity to become all cell types but not placenta.
Cells of most interest to research scientists.
Can develop into cells that are closely related.
Limited number of several cell types.
Make all cell types from the tissue they come from.
Found in many parts of the body.
Can self-renew over a lifetime.
What is the unique property of stem cells which makes them different from a specialised cell?
What does it mean when we say a cell has become ‘differentiated’?
Embryonic stem cells are described as pluripotent whereas adult stem cells are multipotent. Describe in your own words what these terms mean.
Why does adult tissue need stem cells?
Why are research scientists so interested in using stem cells?
We have discussed several types of stem cells. Which type do you think would be most useful to treat human disease? Give a reason for your answer.
Each group has to investigate a disease that could be treated with stem cells. For the disease the group has identified:
describe the condition
identify the organ/system affected
give a reason for why stem cells rather
than drug therapy would be beneficial.