1 / 9

Gene, MicroArray and GA s

Gene, MicroArray and GA s. Ashish Anand Kanpur Genetic Algorithms Laboratory (KanGAL) IIT Kanpur. Overview. What are Genes ? Why study Genes ? What is MicroArray ? How it is Helping ? Where does GA comes ?. What are Genes ?. Alphabet of 4 letters [A T G C] , called nucleotide bases

minniep
Download Presentation

Gene, MicroArray and GA s

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Gene, MicroArray and GAs Ashish Anand Kanpur Genetic Algorithms Laboratory (KanGAL) IIT Kanpur

  2. Overview • What are Genes ? • Why study Genes ? • What is MicroArray ? • How it is Helping ? • Where does GA comes ?

  3. What are Genes ? • Alphabet of 4 letters [A T G C] , called nucleotide bases • DNA • Sequences of ATGC • Double stranded, helical structure • Complementary Properties of Alphabets E.g. A T G C C | | | | | T A C G G • Gene : Nothing but DNA sequence

  4. Why Study Gene ? • Central Dogma of Biology DNA mRNA Protein • mRNA : Sequence of 4 letters [A U G C] • Protein : Sequence of 20 Amino Acids • Gene Encodes Proteins • Regulates functioning of whole system

  5. What is MicroArray ? • A small glass slide or nylon substrates • Each small square represents 1 gene • Uses Complementary Property of DNA sequence • A technology to study large no of Genes in one GO • Gives quantitative measure of Gene Expression

  6. MicroArray : Contd. • Many Technologies • Two Color Vs One Color • Affymetrix widely used

  7. How MicroArray is Helping? • An idea of changed expression levels of genes in • Treated/Disease/Mutant/Knock-out Vs Untreated/Normal/Wild-type • Different Tissues/Cells • Different Developmental Stages • Co-expressed Genes gives an idea of Gene Regulatory Network • Functional roles of different genes and their participation in different cellular and biological processes. • Diagnosis of disease like different cancer types

  8. Where Does GA comes – Few Examples • Classification Problems • Modeling of Gene Regulatory Network

  9. Thank you

More Related