1 / 23

Neurobiological Reading Mechanisms: fMRI Insights into Auditory and Visual Sentence Processing

This article explores the neurobiological underpinnings of reading through advanced fMRI techniques. Focusing on different slice orientations such as sagittal, coronal, and axial, it assesses brain areas involved in semantic processing during auditory and visual sentence tasks. Specific regions, including the temporoparietal and occipitotemporal areas, are analyzed for their roles in mapping orthographic, phonological, and semantic representations, as highlighted in studies by Pugh et al. (2000) and others. The impact of functional connectivity on reading abilities among various demographic groups is also discussed.

minerva-english
Download Presentation

Neurobiological Reading Mechanisms: fMRI Insights into Auditory and Visual Sentence Processing

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. fMRI Setup

  2. slice orientations sagittal coronal axial

  3. SPGR Anatomics (1) resolution in-plane 0.9375 mm2 through-plane 1.5 mm

  4. SPGR Anatomics (2)

  5. SPGR Anatomics (3)

  6. Diffusion-Weighted Imaging (1)

  7. Diffusion-Weighted Imaging (2)

  8. Diffusion-Weighted Imaging (3)

  9. Slice Locations

  10. Auditory versus Visual Sentence Task common print(red) speech(blue) R - L Constable, Pugh et al., (NeuroImage 2004)

  11. An Initial Neurobiological Reading Model (Pugh et al. 2000) • TEMPOROPARIETAL • (DORSAL) • Areas: • supramarginal, angular, superior temporal (Wernicke’s) gyri • Hypothesized Function: • Mapping of orthographic to phonological and semantic representations • ANTERIOR • Areas: • inferior frontal gyrus (including Broca’s area) • One Hypothesized Function: • Articulatory recoding OCCIPITOTEMPORAL (VENTRAL) Areas: occipitotemporal juncture, middle and inferior temporal gyri Hypothesized Function: Linguistically structured memory- based fast word identification system (posterior aspect = “word-form” area)

  12. Auditory versus Visual Sentence Task common print(red) speech(blue) temporoparietal anterior occipitotemporal R - L Constable, Pugh et al., (NeuroImage 2004)

  13. Vasculature Menon & Kim, Trends in Cognitive Sciences, 3(6), 1999.

  14. Vasculature Menon & Kim, Trends in Cognitive Sciences, 3(6), 1999.

  15. Simulated Hemodynamic Response (1) mean = 5000 sd = 100 effect size 0-1%, 0-50 points Gamma function tau=1.08; n=3; delay=3

  16. Variability of the HRF (1) Meizin et al., 2000

  17. Simulated Hemodynamic Response (2) Noise SD = 0 Noise SD = 10 Noise SD = 100

  18. Estimating the Response (3):Simple Subtraction with Overlap Dale & Buckner, 1997

  19. Linear Deconvolution Neuronal activity is modeled as a sequence of point events. slide courtesy of Matthew Brown, University of Western Ontario

  20. Functional Connectivity activations in Shaywitz et al. 2002 older good readers 74 good readers 7-18 yrs 70 dyslexic readers 7-18 yrs

  21. Functional Connectivity seed voxel correlations older good readers

  22. Functional Connectivity Younger Non-Impaired Older Non-Impaired univariate correlations Older Dyslexics Younger Dyslexics

More Related