Nucleophilic Substitutions and Eliminations. Final CHEM 4A Review. Alkyl Halides React with Nucleophiles and Bases. Alkyl halides are polarized at the carbon-halide bond, making the carbon electrophilic
Final CHEM 4A Review
Higher reactant energy level (red curve) = faster reaction (smallerG‡).
Higher transition-state energy level (red curve) = slower reaction (largerG‡).
Step through highest energy point is rate-limiting (k1 in forward direction)
V = k[RX]
Solvation of a carbocation by water
Allows orbital overlap