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Bioengineering with (only) DNA. Dave Zhang 2nd Annual Unither Nanomedical and Telemedical Technology Conference 26 Feb 2009. DNA vs. genetic engineering. Genetic engineering. DNA engineering. A. Z. Ansari, Nature Chemical Biology , 2007. Nanoengineer, by Nanorex

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Bioengineering with only dna
Bioengineering with (only) DNA

  • Dave Zhang

  • 2nd Annual Unither Nanomedical and Telemedical Technology Conference

  • 26 Feb 2009


Dna vs genetic engineering
DNA vs. genetic engineering

Genetic engineering

DNA engineering

A. Z. Ansari,

Nature Chemical Biology, 2007

Nanoengineer, by Nanorex

http://nanoengineer-1.com/content/index.php?option=com_content&task=view&id=37&Itemid=47


Dna abstraction
DNA abstraction

Michael Ströck,

http://en.wikipedia.org/wiki/File:DNA_Overview.png


Structures
Structures

Cell wall

Cilia

Actin and myosin

Lacey Samuels,

https://www.biomedia.cellbiology.ubc.ca/cellbiol/user/scripts/qry_media_id.php?media_id=212

http://online-media.uni-marburg.de/histologie/introhis/HIS/txt/muscsem/musc01_sem.htm

C. Daghlian,

http://refm.dartmouth.edu/images/mammalianLungSEM/source/9.html


Structures

2 um x 8 um

500,000 tiles!

Two-dimensional lattice

Aperiodic structures

Three-dimensional shapes

E. Winfree, F. Liu, L.A. Wenzler,

N.C. Seeman, Nature 1998

Y. He, T. Ye, M. Su, C. Zhang, A.E. Ribbe,

W. Jiang, C. Mao, Nature 2008

P. Rothemund, Nature 2006


Logic and actuators
Logic and actuators

Yum!

Granite

Amoeba

Algae

Micrographia,

http://www.micrographia.com/specbiol/protis/homamoeb/amoe0100/amoeba21.htm


Logical processing

Boolean Logic


Logical processing
Logical processing

Output

Input 1

Input 2

Logical AND gate substrate

D. Y. Zhang, in preparation


Logical processing1
Logical processing

D. Y. Zhang, in preparation


Logical processing2
Logical processing

NAND gate is universal!

D. Y. Zhang, in preparation


Actuators and motors
Actuators and motors

B. Yurke, A.J. Turberfield, A.P. Mills, F. C. Simmel, J.L. Neumann,

Nature 2000


Amplification and reproduction

Jeff Hardin,

http://worms.zoology.wisc.edu/dd2/echino/cleavage/intro.html

http://www.bunny-rabbits.com/

http://www.kindplanet.org/thesanctuary.html



Amplification and reproduction

Cons:

Spontaneous generation

Not really alive:

more like crystallization in a supersaturated solution

Pro:

If we know what we’re looking for, we can amplify its concentration dynamically.

D. Y. Zhang, A.J. Turberfield, B. Yurke, E. Winfree, Science 2007



Interaction with general chemistry
Interaction with general chemistry

Small organic group

Boom!

Z. J. Gartner, B. N. Tse, R. Grubina, J.B. Doyon,

T.M. Snyder, D.R. Liu, Science 2004

Adapted from David Liu’s website:

http://evolve.harvard.edu/rschdts.htm#DTS


Dna engineering as a nanomedical tool
DNA engineering as a nanomedical tool

  • Instrument-free disease detection

  • Embedded control of apoptosis

  • Control of developmental biology


Parting thought
Parting Thought

http://www.kurzweilai.net/articles/images/Carlson(PaceAndProliferation)figure1.gif


Thanks for listening
Thanks for listening!

(and thanks to the following for their money:)


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