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Aim of Project: Identify clinical and laboratory predictors of paradoxical TB-IRIS

Role of IL-6 as a predictor of Paradoxical TB IRIS in HIV Patients with Pulmonary TB in a cohort from India Gopalan Narendran , Bruno Andrade, Alan Sher , Sudha S ubramanium , Chockalingam Chandrasekhar, Soumya Swaminathan , Irene Sereti.

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Aim of Project: Identify clinical and laboratory predictors of paradoxical TB-IRIS

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  1. Role of IL-6 as a predictor of Paradoxical TB IRIS in HIV Patients with Pulmonary TB in a cohort from India GopalanNarendran, Bruno Andrade, Alan Sher , SudhaSubramanium, Chockalingam Chandrasekhar, SoumyaSwaminathan, Irene Sereti Aim of Project: Identify clinical and laboratory predictors of paradoxical TB-IRIS Intramural NIH to India Grant

  2. * p <0-05,**p<0.01,*** p<0.001

  3. Cytokine profile

  4. Profile of innate responses –at baseline and at IRIS/M3 IL-6 at baseline and at IRIS/M3 CRP at baseline and at IRIS/M3

  5. Biomarker candidates for HIV-TB IRIS identified in our Cohort study in India Data from each biomarker represent pre-ART values Data were adjusted by age, time to ART, CD4 count, CD4CD8 ratio, HIV RNA levls

  6. Conclusion Paradoxical TB-IRIS among culture positive PTB -caused by activation of both innate and adaptive immune responses • Predictors include high Viral Load, high monocyte count , Low CD4, Low CD4/CD8 Ratio, HCT and HB at baseline • IL-6 levels at baseline poses to be a promising predictor • Combinations of these markers can be useful to predict the disease and could be possible drug targets in future Barber DL et al.

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