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Innovative Biotech Ltd - Fighting HIV/AIDS in Nigeria

Innovative Biotech Ltd in Nigeria is conducting research on HIV vaccines, drug resistance, and co-infections. Challenges in engaging subjects include skepticism and resistance, but the company provides advanced infrastructure for studies.

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Innovative Biotech Ltd - Fighting HIV/AIDS in Nigeria

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  1. Innovative Biotech LtdNigeria Dr Simon Agwale

  2. General overview (1) • Nigeria is the tenth largest country in the world and the most populous in Africa. It is situated within sub Saharan Africa which harbors about 67% of the world HIV/AIDS burden • It has an estimated population of 120 million (1999), representing over one fifth of the total population of the African continent • It is a democratic Federal Republic consisting of 36 states and the Federal Capital Territory (FCT) • The literacy level is estimated to be 55%

  3. General overview (2) • Ever since HIV was reported in the country in 1996, the infection rate has continued to rise steadily from less than 0.1% in 1987, to 1.8% in 1991, to 5.8% in 2001, with a slight decrease in 2003 sentinel survey to 5.0% • The HIV prevalence rates in the two States chosen for the study are 12% for Benue and 9% for Nasarawa. Most of the female sex workers have low literacy rates • Presently, no study has effectively addressed the incidence of the disease among this group till date

  4. HIV prevalence in Nigeria (1)

  5. HIV prevalence in Nigeria (2) • According to the National survey, HIV prevalence rate among female sex workers in Nigeria has remained high, and is on the increase from 17.5% in 1991 through 22.5%(1993), to 35.6% in 1995 • Female sex workers constitutes an important core group of HIV transmission to the general population

  6. Site overview • Innovative Biotech Ltd (IBL) is a company registered in Nigeria • Investigators have experience with clinical research • Current research at IBL includes: • Development of HIV candidate vaccines • Subtyping of HIV 1 and 2 in Nigeria • HIV drug resistance Surveillance in Nigeria • Prevalence of co-infection of HIV with Hepatitis B & C • Subtyping of Hepatitis C virus in Nigeria • Cross-sectional HIV incidence study among female sex workers based at brothels in Nasarawa and Benue states

  7. Site locations

  8. Interim study findings ( Feb. 07- April 11, 2006)

  9. Challenges • Subjects being skeptical of our intention- • such trials are relatively new in the area • Not comfortable with staff leaving with their blood samples • Some think their blood will be used for ritual purpose • Resistance sometimes from their male clients • Brothel owners not being cooperative in some places • Outright refusal to grant us entrance in some brothels • Resistance to the ideal of someone witnessing after signing the informed consent form

  10. Current infrastructure • DNA sequencer-DNA analyses • Real time PCR for Viral load quantification • Facs count for CD4/8 measurement • ELISA washer and reader • Chemistry analyzer • Vaccine administration and post-vaccination surveillance • Training and capacity building for health workers, organizations and the general public • Treatment services for HIV an other tropical infectious diseases • Internet and Data entry/analyses • Pharmacy • Counselling unit

  11. Reception

  12. Data entry and processing

  13. Serology lab

  14. Lab equipment

  15. IT Equipment

  16. IBL Boardroom

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