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Biotechnology R&D in India. Dr. Renu Swarup , Adviser Department of Biotechnology Ministry of Science & Technology Government of India. 28 February, 2013. What is Biotechnology?. Biotechnology is ….

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slide1

Biotechnology R&D in India

Dr. RenuSwarup, Adviser

Department of Biotechnology

Ministry of Science & TechnologyGovernment of India

28 February, 2013

what is biotechnology
What is Biotechnology?

Biotechnology is ….

“Any technique that uses living organisms, or substances from those organisms, to make or modify a product to improve plants or animals, or to develop microorganisms for specific uses”.

india s research scenario
India’s Research Scenario
  • Population 1.2 billion
  • No. of researchers - 0.15 million ( 140 per million)
  • No. of universities - 457
  • No. of publications – 65,000 per year ( 3.1% share)
  • About 1% of GDP is spent on R&D
  • World share of output over 2006-2010 – 3.3%
  • Citation impact 2006-2010 – 0.68
  • Narrowing gap between India and established economics
india major s t agencies
India – Major S&T Agencies
  • Ministry of Science and Technology
    • Department of Biotechnology (DBT)
    • Department of Science and Technology (DST)
    • Council of Scientific and Industrial Research (CSIR)
  • Ministry of Earth Sciences
  • Department of Atomic Energy (DAE)
  • Department of Space (DoS)
  • Ministry of New & Renewable Energy
  • Ministry of Health & Family Welfare
    • Department of Health & Family Welfare
    • Indian Council of Medical Research (ICMR)
  • Ministry of Agriculture
    • Indian Council of Agricultural Research (ICAR)
  • Ministry of Environment and Forests
department of biotechnology
Department of Biotechnology

1982 : National Biotechnology Board (NBTB)

1986 : Department of Biotechnology (DBT)

2012 : Biotechnology Industry Research Assistance Council (BIRAC)

slide6

VISION

“Attaining new heights in biotechnology research, shaping biotechnology into a premier precision tool of the future for creation of wealth and ensuring social justice – specially for the welfare of the poor”.

slide10

Cell Science

Plant Genome Research

Immunology

Crop Biotechnology

and Transgenics

Neurosciences

New Generation Vaccines

Micropropagation

Diagnostics Molecular probes

BIOTECHNOLOGY FOR THE NEW MILLENIUM A FEW GLIMPSES

Biodiversity Inventorisation, Characterisation, Conservation

Gene therapy and functional genomics

Prospecting of Genes and Molecules

Bioproduct Development Down Stream Processing

Environmental Pollution abatemant

Patenting in Biotechnology and Biosafety

Special Societal Programmes

Animal Biotechnology

Bioinformatics

Human Resource Development

Aquaculture and Marine Resource

biotechnology pervades multiple facets of life
Biotechnology pervades multiple facets of life

Agriculture

    • Transgenics crops, designer breeding, plants as biofactories, biopesticides, biofertilizers, diagnostics

Human health

    • Biodrugs, vaccines, diagnostics, biomarkers, cell & tissue engineering products, artificial organs, nano based drug delivery systems, biobased implants and devices

Animal

  • Transgenics, vaccines, diagnostics, feed, biofactories

Bioresources

    • Bioactives and drugs, biological processes, microbial prospecting

Environment

    • Bioremediation, pollution abatement, biofuels

Industrial /Manufacturing

  • Enzymes, biomass based bioproducts, disposable GMP biofactories, plant based bioactivesbionutraceuticals, biosensors, bioequipment and enabling technology platforms
biotechnology is a multidisciplinary field integrated development is essential
Biotechnology is a multidisciplinary field Integrated development is essential
  • Biological and material science
  • Physical Science
  • Chemical Science
  • Engineering – bioengineering, electronics
  • Medicine
  • Agronomics
  • Aquaculture
  • Animal Science
  • Energy Bioscience
  • Environment Science
  • Bioresource
  • Nano Science
  • Forestry
  • Investment and Finance
  • Management
  • Law
dbt technology focus

DBT Technology Focus

Vaccines and Diagnostics -Human , Animal

Stem Cells

Implants and devices

Transgenics and marker assisted breeding

Animal vaccines, feed and breeding

Bioresources utilization (drugs, antivirals others)

Food and nutrition technology

Bio-pesticides and bio-fertilizers

Novel and green manufacturing /technologies

slide14

Genomics based strategy is now required for drought, salinity, heat ….

  • Strategic basic research
    • Discover genes, genomic regions and their function
  • Designer breeding
    • Transgenics
    • Molecular assisted breeding
  • New Models of R&D
  • Major capacity building in genomics and designer breeding
slide15

Genome Initiative: India Moves Ahead !

Tomato

Rice

Sugarcane

Chickpea

Wheat

Coffee

Complete

Bacterial Genome

Chromosome 11

Chromosome 5

Silk worm

slide16

National Programme on Energy Biosciences

Bioethanol

  • Re-engineered feed stock
  • Re-engineered microorganisms
  • Process optimization

Algal Biofuel

  • Collection and characterization
  • Establishment of repositories
  • Development of production system

Capacity Building

Energy Bioscience Centre

  • Energy Bioscience Chairs
  • Energy Bioscience Overseas Fellowships

Biodiesel

  • Quality planting material
  • Improved feed stock
  • Process optimization

Next generation Biofuels

  • Biohydrogen
  • Biobutanol
  • Synthetic biology

More than 53 research institutes, universities and industries involved

slide17

NEERI

Effluent Treatment plants /contaminated sites

NCCS

Western Ghats, Insect guts

GNDU

Wet land ecosystems of North West India

7000 isolates

/month

MSSRF

Eastern Ghats, and Mangroves Area

Univ Delhi

Hot Springs of Himachal Pradesh

IBSD

North East area

ILS

Extremophiles from Orissa, Bihar and West Bengal

IGIB

River Sediments

NIO

Marine isolates

Screening for Bio-Molecules from Microbial Diversity

from Different Ecological Niches

slide18

Country’s largest Microbial Culture Collection Centre Set Up at NCCS, Pune

Recognized as International Depositary Authority (IDA) w.e.f. 9th April 2011

  • Has a capacity to hold more than 2,00,000 bacteria and fungi
  • Presently holding 100,000 culture
slide19

Environmental Biotechnology

  • Oil Zapper
  • Bacterial consortium (5 strains) - ‘Oilzapper’ for remediation of oily sludge and crude oil spills developed by TERI, New Delhi and demonstrated at a number of refineries
  • Technology transferred to Bharat Petroleum Corporation Ltd, Mumbai and Sriram Biotech Ltd.; used in Kuwait and Oman on contract basis
stem cell research strategy
Stem Cell Research - Strategy

Basic Stem Cell Research

Stem Cell Bank

Stem Cell Therapy Production Unit

Stem Cell Clinical Trials

Licensed Product Manufacture

vaccine grand challenge vaccines in trials or transferred to industry
Vaccine Grand ChallengeVaccines in Trials or Transferred to Industry
  • Rotaviral Diarrhoea
  • Japanese Encephalitis
  • Rabies
  • Dengue
  • Typhoid
  • Malaria
  • Leprosy
  • Anthrax
  • Cholera
  • Infectious Bovine Rhinotracheitis

India A Vaccine Manufacturing Hub

slide23

Stanford-India Biodesign Programme

Creating Entrepreneurs

A better way to gain intra-osseous access in emergency patients.

An effective and consistent way to deliver chest compressions to sudden cardiac arrest victims

Esophagus

Entry

Trachea

Entry

Non-invasive, rapid and definitive way of airway management.

new institutions
New Institutions
  • National Institute of Biomedical Genomics, Kalyani
  • Regional Centre for Biotechnology, Faridabad, Haryana
  • National Institute of Animal Biotechnology, Hyderabd
  • Translational Health Sciences and Technology Institute, Faridabad
  • National Agri-Food Biotechnology Institute and Bioprocessing Unit, Mohali, Punjab
  • Institute of Stem Cell Biology and Regenerated Medicine, Bangalore
  • Institute of Bioinformatics & Computational Biology
  • Institute of Marine & Microbial Biotechnology
  • Biotechnology Regulatory Authority of India (BRAI)
  • Institute of Biodesign, Bioscience & Bioengineering (includes Medical Centre)
  • Institute of Chronic Disease Science & Biotechnology
  • Infectious Science & Biotechnology Institute in North East (linking to THSTI as partner for training & Education)
slide26

Research Facilities ,Resources,and Services

  • Automated high-throughput DNA sequencing facilities
  • Phytotron Facility
  • National Containment - cum - Quarantine Facility for transgenic
  • planting material
  • National Plant Gene Repository
  • Technology Platform for Translational Research on Transgenic Crops
  • International Depository authority for patent deposits of
  • microorganisms
  • Access to European Synchtron Research Facility, Grenoble
  • Primate Research Platform
  • Microbial Respository
  • National Certification system for Tissue culture raised Plants
  • Core Immunological Laboratory for vaccine immune responses
  • Biomolecular characterisation centre
bioinformatics network
Bioinformatics Network
  • Total number of Centres - 168
  • Centre of Excellences (CoEs) - 5
  • Distributed Information Centres (DICs)- 11
  • Distributed Information Sub Centres- 50
  • Bioinformatics Infra. Facility - 101
  • Apex BTIC - 1
  • Graphics Facility - 6
  • MSc/M.Tech/Diploma - 5
  • R&D Projects - 97
developing the human resource
Developing the Human Resource
  • The Department of Biotechnology is implementing an integrated programme of human resource development in biotechnology comprising of postgraduate teaching programmes in biotechnology to create a pool of talented students and upgrading skills of mid career scientists and faculty by specialized training in leading national laboratories and overseas laboratories .
    • Postgraduate M.Sc./ M. Tech teaching programme
    • Details of ongoing teaching programmes
    • PG diplomas (Post M.Sc. /M.D./MS/ M.Tech)
    • Biotech industrial training programme
    • Training programmes
    • Star college scheme for strengthening of life science and biotechnology education and training at undergraduate level
career development opportunities
Career Development Opportunities
  • Rapid Grant for Young Investigators (RGYI)
  • FAST TRACK Scheme for Young Scientists
  • National Bioscience Awards for Career Development
  • Innovative Young Biotechnologist Award (IYBA)
  • Biotechnology Career Advancement and Re-orientation (Bio-care) Programme / Awards for Women Scientists
  • Women Scientists Scheme (WOS-A)
  • Tata Innovation Fellowship
  • Innovation in Science Pursuit for Inspired Research (INSPIRE)
re entry fellowship grant schemes
Re-entry Fellowship / Grant Schemes
  • Ramanujan Fellowship
  • Ramalingaswamy Fellowship
  • Energy Bioscience Fellowship
  • Wellcome Trust Fellowship
slide31

New Global Partnerships

Indo-Australia

Indo-Canada

Indo-Denmark

Indo-EU

Indo-Finland

Indo-German

Indo-Japan

Indo-Norway

Indo-Swiss

Stanford Biodesign

Indo-UK

Indo-US

Collaboration with IAVI, GATES

Foundation, MVI, PATH,

WellcomeTrust

International partnerships HST,

slide33

BIRAC to Nurture Industry R&D

30% budget to be spent on PPP

drivers of innovation
Drivers of Innovation
  • Real Public R&D expenditure
  • R&D personnel per million persons
  • Education share of GDP
  • IP protection
  • Cluster specific environment
  • R&D funded by industry
  • R&D performed by universities
  • Global / National Model
slide36

India is in 12th rank in the world in biotechnology and 3rd largest in Asia-Pacific after Japan and Korea.

  • The Sector employees approximately 20,000 scientists and over 352 companies drive it towards further growth.
slide37

Science Clusters

Strength of Synergy

Faridabad

Mohali

Bangalore

Teaching, discovery, creativity, innovation as a federation

institutional redesign mechanisms to make industry academia interaction happen
Institutional RedesignMechanisms to make industry –academia interaction happen
  • Concept and design centers
  • Technologies licensing and management
  • Incubation
  • Ignition, pre competitive grants
about birac
About BIRAC

A ‘Not for Profit Company’ set up by Department of Biotechnology (DBT), Government of India as an Interface Agency to strengthen and empower the emerging Biotech enterprise to undertake strategic research and innovation, addressing nationally relevant product development needs.

to promote innovation high risk research product development and commercialization
To promote innovation, high risk research product development and commercialization

Biotechnology Industry Partnership Programme (BIPP)

Small Business Innovation Research Initiative (SBIRI)

Technopreneur Promotion Program (TePP)

Public-Private Partnership Funding Options

Pharmaceutical Research & Development Support Fund (PRDSF)

Biotechnology Ignition Grant (BIG)

Contract Research/Service Scheme (CRS)

slide44

The Vision and Opportunity for Indian Biotechnology :

An $100 billion dollar industry by 2025.

science technology and innovation policy 2013
Science, Technology and Innovation Policy 2013

The guiding vision of aspiring Indian STI enterprise is to accelerate the pace of discovery and delivery of science-led solutions for faster, sustainable and inclusive growth.

slide46

A Biotechnology Enterprise of future

BIRAC

Innovation

Entrepreneurship

Public -Private -

Partnership

  • DBT
  • Science
  • People
  • Infrastructure
  • Legislations

BRAI

Regulation