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Effects of Resveratrol and Melatonin on Drosophila melanogaster Under Paraquat-Induced Stress

This study investigates the impact of resveratrol and melatonin on the survival and lifespan of Drosophila melanogaster subjected to paraquat-induced oxidative stress. With the increasing prevalence of alcohol-related disorders and a focus on antioxidant properties, our findings aim to clarify whether pre-exposure to these compounds can enhance survivability. The hypotheses propose that Drosophila pre-treated with resveratrol and melatonin will exhibit improved survival rates and extended lifespans compared to the control group, thereby contributing to our understanding of oxidative stress responses.

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Effects of Resveratrol and Melatonin on Drosophila melanogaster Under Paraquat-Induced Stress

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  1. The Effects of Resveratrol and Melatonin on Drosophila melanogaster with Paraquat Induced Oxidative Stress By Anthony Anastasio

  2. Need Figure 1 Over the passed 6 years, disorders from alcohol have increased Figure 2 Wine still remains the leased consumed alcoholic beverage

  3. Oxidative stress

  4. Antioxidants

  5. Resveratrol • Found in the skin of grapes that are used in the fermentation of red wine. • Found in plants as a defense system against disease.

  6. Bass (2007) • When drosophila exposed to resveratrol, no increase in lifespan is shown Effect of Resveratrol on the Life span of C. Elegans

  7. Bauer (2004) • Drosophila showed an increase in lifespan with resveratrol supplements

  8. Bonilla and Molero (2006) • Drosophila exposed to Melatonin, Serotonin, Lipoic acid, and Ascorbic acid The survivability of Drosophila shown after paraquat induced oxidative stress with different pre exposures

  9. Purpose • To determine the effects of resveratrol and melatonin on the survival rate of drosophila after paraquat induced oxidative stress.

  10. Hypothesis • Null Hypothesis- Drosophila will have the same survival rate after paraquat induced oxidative stress in all groups and no change in life span will occur. • Alternative Hypothesis- Drosophila that are pre-exposed to resveratrol and melatonin will have a higher survival rate after paraquat induced oxidative stress and a longer life span then the control group.

  11. Budget

  12. Do-ability • Drosophila cultures are available • Exposure to Resveratrol and Melatonin • Procedures that been done in lab

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