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Bioterrorism & Biological War

Bioterrorism & Biological War. Prof. A K Mudgal Govt College Aron M.P INDIA. GENES DONOT MAKE YOU BAD, THEY MAKE PROTEINS. Have you ever noticed this Sign. What is Bioterrorism. BW.

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Bioterrorism & Biological War

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  1. Bioterrorism& Biological War Prof. A K Mudgal Govt College Aron M.P INDIA

  2. GENES DONOT MAKE YOU BAD, THEY MAKE PROTEINS

  3. Have you ever noticed this Sign

  4. What is Bioterrorism

  5. BW • Biological warfare (BW) is the use of organisms that cause disease to harm or kill an adversary’s military forces, population, food or livestock. • Living organic germs, like anthrax, are a major example of biological weapons. • Byproducts of organisms, such as toxins. An example is botulinum. • Biological agents are much deadlier, pound for pound, than chemical agents. It has been estimated that 10 grams of anthrax could kill as many people as a ton of the nerve agent Sarin.

  6. Biological WAR • Use of virus, Bacteria, fungi and other biological agents for mass destruction • Clandestine operation • Bioterrorism

  7. Bioterrorism • 1993 - Japan - Aum Shinrikyo anthrax release in Kameido  • 2001 USA Anthrax

  8. 1972 Biological Weapons Convention (BWC), signed by over 100 countries • Biological weapons are so lethal that one gram of purified botulinum toxin could kill 10 million people.

  9. At the time of the Korean War the US had only one agent, brucellosis (agent US), which is caused by Brucella suis. The original weaponized form used the M114 bursting bomblet in M33 cluster bombs

  10. Biological agents • A biological agent is a bacterium, virus, prion, fungus, or biological toxin that can be used in bioterrorism or biological warfare. More than 1200 different kinds of biological agents have been described and studied to date

  11. Bacillus anthracis. • Causes anthrax • If bacteria are inhaled, symptoms may develop in two to three days • Initial symptoms resembling common respiratory infection are followed by high fever, vomiting, joint ache and labored breathing, and internal and external bleeding lesions • Exposure is fatal

  12. Brucellosis • Maltese fever • Man, livestock, Lethal • Psittacosis :parrot fever • Chlamydophila psittaci : lethal

  13. Botulinum toxin • Cause of botulism, produced by Clostridium botulinum bacteria • Symptoms appear 12 to 72 hours after ingestion or inhalation • Initial symptoms are nausea and diarrhea, followed by weakness, dizziness and respiratory paralysis, leading to death • Antitoxin can sometimes arrest the process.

  14. Q fever • Coxiella burnetii • threatening acute respiratory distress syndrome (ARDS),

  15. Yersinia pestis • Causes bubonic plague, the Black Death of the Middle Ages • If bacteria reach the lungs, symptoms--including fever and delirium--may appear in three or four days • Untreated cases are nearly always fatal. Vaccines can offer immunity, and antibiotics are usually effective if administered promptly

  16. Ebola • Ebola virus • Highly contagious and lethal • May not be desirable as a biological agent because of uncertain stability outside of animal host • Symptoms, appearing two or three days after exposure, include high fever, delirium, severe joint pain, bleeding from body orifices, and convulsions, followed by death • No known treatment. Supportive therapy

  17. SmallpoxVariola

  18. H1N1

  19. The Big Five • M1 Biodart (E1) A 7.62mm rifle cartridge with exterior grooves filled with either botulinum toxin A

  20. The “Eight Ball”

  21. Anti-agriculture BW • Second world war: herbicide • Biotoxins • Wheat blast & rice blast

  22. Parthenium • Eichornia

  23. GMO

  24. Head Scab of Wheat • Causal agent: Fusarium spp. • Disease: Fusarium head blight • Effects: • Early infection prevents kernel filling • Late infection - trichothecene mycotoxins • Cytotoxic – intenstines, bone marrow, lymph nodes, spleen and thymus • Leads to low white blood cell count and bone marrow atrophy • Estimated LD50 – 0.5 mg/kg • Burning sensation, spotty hemorrhages, internal hemorrhages, vomiting

  25. Head Scab of Wheat • Fusarium is not host specific • Soil borne • Wheat resistance known but not developed • Chemical control effectiveness dependent on timing and only 50-60% effective.

  26. China Taiwan Iran Cuba Israel Russia USA North Korea Iraq (DNF) Syria Egypt Japan Countries With or Suspect of Having BW Programs

  27. White coat

  28. Entomological Warfare • Infected Insects Colorado potato beetle

  29. Japan in WW II killed 500000 chinese.

  30. High level threats by UN • Biopen

  31. INDIAN CONCERN

  32. This is Black Biology

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