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Enhancement of Vpr-mediated cell cycle arrest by DCAF1 in G2 phase

This study investigates the role of DCAF1 in amplifying Vpr-induced cell cycle arrest specifically in the G2 phase. Results demonstrate a potentiation effect when DCAF1 interacts with Vpr, leading to an extended arrest in G2. The findings shed light on the molecular mechanisms underlying this process.

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Enhancement of Vpr-mediated cell cycle arrest by DCAF1 in G2 phase

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  1. Vpr Tubulin 400 mock DCAF1 300 G2/G1=0.59 G2/G1=0.48 Flag-DCAF1 - + + + + 300 - - + - - HA-Vpr 200 - - - + - HA-VprR90K 200 - - - - + HA-VprR90D 100 100 0 0 250 200 300 200 DCAF1 DCAF1 DCAF1 150 150 VprR90K VprR90D Vpr 200 100 G2/G1=2.08 G2/G1=0.47 G2/G1=2.81 100 100 50 50 0 0 0 Additional file 2: Figure S2 A B 0 200 400 600 800 1000 0 200 400 600 800 1000 Cell number 0 200 400 600 800 1000 0 200 400 600 800 1000 0 200 400 600 800 1000 DNA content

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