TUBULOINTERSTITIAL DISEASES Terminology. Tubulointerstitial nephritis: Primary - Inflammation limited to tubules & with uninvolved or minimally involved glomeruli/vessels . Acute - Sudden onset & rapid decline in renal function associated with interstitial edema
Prolonged ischemia due to:
Shock: postoperative, intra-operative, post-traumatic, septic, hypotensive
Hemorrhage:postpartum hemorrhage, abruptio placentae
Other: severe burns, transfusion accidents, dehydration, heat stroke, crushing injuries, non-traumatic rhabdomyolysis, paroxysmal hemoglobinuria etc.
Therapeutic agents :
chemotherapeutic agents, etc.
(1) with / without obstruction
(2) ascending infection through vesicoureteral reflux (3) from hematogenous dissemination.
(1) obstructive with recurrent infection
(2) non-obstructive with vesicoureteral reflux → reflux nephropathy
role of vesicoureteral reflux and infected urine