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Figure 1. Figure 2. Somatic Mutation Summary. tumor mutant reads > 10 normal mutant read = 0 tumor mutant fraction > 0.1 normal reference reads > 10. 1030478A28. 1050716A. 3051000A. 98-07-F009a. Figure 3. validation by sanger sequencing of gDNA. P952R. normal. ESYT1. tumor.

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slide2

Figure 2

Somatic Mutation Summary

tumor mutant reads > 10

normal mutant read = 0

tumor mutant fraction > 0.1

normal reference reads > 10

1030478A28

1050716A

3051000A

98-07-F009a

validation by sanger sequencing of gdna

Figure 3

validation by sanger sequencing of gDNA

P952R

normal

ESYT1

tumor

K217Q

normal

RYBP

tumor

slide5

Distribution of Ratio of cDNAras over gDNAras

ras = mutant/(wt +mutant)

Ratio of cDNA-ras / gDNA-ras

Mean = 1.54, p-value = 0.0262

rna seq of cgi samples
RNA-seq of CGI samples?
  • Identify mutations and gene expression in large number of genes
  • Using alellic gene expression can we classify mutations into driver and passenger?
  • mRNA-seq of breast cancer samples selectively identified driver mutations?