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Molecular Motors

Molecular Motors. Arafath Hussain Stevens Institute of Technology Dr. Arthur Ritter. Needs and Background. NIRT Application - Nanoscale Interdisciplinary Research Team 15 undergraduate BME students. Nano-scale autonomous device No academic credit.

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Molecular Motors

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  1. Molecular Motors Arafath Hussain Stevens Institute of TechnologyDr. Arthur Ritter

  2. Needs and Background • NIRT Application - Nanoscale Interdisciplinary Research Team • 15 undergraduate BME students • Nano-scale autonomous device • No academic credit

  3. What is Molecular Motor? • Chemical energy into Mechanical work - Nanometer scale • Examples of Motors: - Kinesin • - Myosin • - Dynein

  4. Develop a platform of Nano devices in an environment Hood Flagella Petri dish Plates Autoclave Flask Objective and Materials • Incubator • Agar media • Cells

  5. Weigh out the agar Autoclave the solution Let the flask cool down Pour into Petri Dishes Spread the algae Leave it for couple of days Procedure

  6. Not enough experiments More information More analysis Expected: Get the bacteria with flagella in it. Results

  7. "Rotation of the c subunit oligomer in fully functional F1Fo ATP synthase" by Satoshi P. Tsunoda, Robert Aggeler, Masasuke Yoshida, and Roderick A. Capaldi in Proc Natl Acad Sci U S A (2001) volume 98 pages 898–902. Full text at PMC: 14681 Mitsuya Shirashi, Xuemei Wang, Michael P. Walsh, Gary Kargacin, Kathy Loutzenhiser, Rodger Loutzenhiser. “Myosin heavy chain expression in renal afferent and efferent arterioles: relationship to contractile kinetics and function.” The FASEB Journal. Oct 2003. Fasebj. 16 Oct 2003 < http://www.fasebj.org/cgi/reprint/03-0096fjev1.pdf> Isabel Schuchardt, Daniela Abmann,Eckhard Thines,Christian Schuberth, and Gero Steinberg. "Myosin-V, Kinesin-1, and Kinesin-3 Cooperate in Hyphal Growth of the Fungus Ustilago maydis." Mol Biol Cell (2005): 5191–5201. Jon Kull, F., et al. "Crystal structure of the kinesin motor domain reveals a structural similarity to myosin." Departments of Biochemistry/Biophysics (Crystal structure of the kinesin motor domain reveals a structural similarity to myosin): 550-555. Hirokawa, N. (1998). Kinesin and dynein superfamily proteins and the mechanism of organelle transport. Science 279, 519-526 Vale, R.D. and Milligan, R.A. (2000). The way things move: looking under the hood of molecular motor proteins. Science 288, 88-95. Schliwa, M. and Woehlke, G. (2003). Molecular motors. Nature 422, 759-765 Vale, Ronald D. "The Molecular Motor Toolbox for Intracellular Transport." Department of Cellular and Molecular Pharmacology (2003): 467-480. References

  8. Acknowledgements Dr. Arthur Ritter Esther Trupti Co: Jae Yoo Dr. Sat Memorial Sloan-Kettering Cancer Center Harlem Children Society And to all of you for listening!

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