Hetastarch Administration in Patients Undergoing Open Heart Surgery in Association with Cardiopulmonary Bypass (CPB). Blood Products Advisory Committee June 14, 2002 Laurence Landow MD. Questions for the Committee.
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Blood Products Advisory Committee
June 14, 2002
Laurence Landow MD
Venous tubing (from the right atrium) Surgery in Association with Cardiopulmonary Bypass (CPB)
Arterial line microfilter
Arterial tubing (to the aorta)
Chest 2000; 118:1616-1620
Anesth Analg 2000; 90:801-7
Ann Thorac Surg 1997; 63:78-83
Ann Thorac Surg 2001; 72:527-34
~ 200 subjects required to detect an absolute 10% increase in blood loss
Knutson et al (N=445): confounded with respect to CPB time and temperature
Canver et al (N=887): biased with respect to patient selection and treatment
Cope et al (N=189): confounded with respect to fluid managementReason # 7