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Explore the evolution and potential of microfluidic logic systems in biomolecule detection. Discover innovations to increase sensitivity and complexity, with insights from key studies from the past decades.
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Microslots and Microfluidic Logic • Yael Maguire and Manu Prakash • Oct 12, 2006
If we make life... Sweedler et al, Chem Rev, 1999 , Sweedler/Whitesides et al, APL, 1997 • how will we understand what we’ve made? Walton et al, AnalChem, 2003 Massin et al, JMR, 2003 • 1013-1014(100pmols -1nmol) biomolecules
160 um plug 8x more sensitive than best planar probe 1014 molecules
Future 1010 molecules at room temperature 100 sensors in 5mm2
Complexity in fluid manipulation 2005 2006 2007 1960’s Moore’s Law for Microfluidics Increasing Complexity
Microfluidic Bubble Logic Nonlinearity Bistability Cascadability Feedback