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Aquaculture Drugs—Update*

Aquaculture Drugs—Update*. Rosalie (Roz) Schnick Michigan State University RozSchnick@Centurytel.net http://ag.ansc.purdue.edu/aquanic/jsa/aquadrugs/index.htm *Presented at the National Association of State Aquaculture Coordinators, Louisville, Kentucky, June 2-5, 2004.

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Aquaculture Drugs—Update*

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  1. Aquaculture Drugs—Update* Rosalie (Roz) Schnick Michigan State University RozSchnick@Centurytel.net http://ag.ansc.purdue.edu/aquanic/jsa/aquadrugs/index.htm *Presented at the National Association of State Aquaculture Coordinators, Louisville, Kentucky, June 2-5, 2004

  2. Major Initiative Nearing Final Completion • Federal-State Aquaculture Drug Approval Partnership Project (=IAFWA Project) • Main partners • Aquatic Animal Drug Approval Partnership Program (AADAP) • Upper Midwest Environmental Sciences Center (UMESC) • Harry K. Dupree Stuttgart National Aquaculture Research Center (SNARC) • Eight years, formal portion ended September 2002 • $12+ million • 9 drugs (marked in turquoise)

  3. IAFWA Project Submissions & Acceptances (9/03 – 3/04)

  4. IAFWA Project Submissions & Acceptances (9/03 – 3/04)

  5. STATUS OF EFFORTS TOWARD APPROVALS—AQUACULTURE THERAPEUTANTS

  6. Completed or Nearing Completion—Oral Antibacterials • Erythromycin (BPA, NRSP-7, University of Idaho) • Bacterial kidney disease—salmon • Florfenicol (was IAFWA Project, MCGP, & sponsor) • Furunculosis columnaris disease—freshwater-reared salmonids (AADAP, UMESC) • Coldwater disease—freshwater-reared salmonids (AADAP, UMESC) • Enteric septicemia—catfish (UMESC) • Systemic columnaris disease—freshwater-reared salmonids & catfish (AADAP & UMESC)

  7. Completed or Nearing Completion—Oral Antibacterials (continued) • Oxytetracycline (oral)—approvals—various diseases—catfish, salmonids, & lobsters • Coldwater disease—all freshwater-reared salmonids (AADAP, UMESC) • Systemic columnaris disease—steelhead trout (AADAP, UMESC) • Romet-30®—approvals—various diseases—catfish & salmonids • Romet-TC®—improved palatability for top coating—accepted November 2003 • Sulfamerazine—approved for furunculosis—salmonids (sponsor not currently distributing product)

  8. Work Underway—Oral Antibacterials (continued) • Amoxicillin (sponsor, Kent SeaTech, NRSP-7, SNARC) • Streptococcus—hybrid striped bass & tilapia (work underway) • Oxytetracycline (oral)—approvals for catfish, salmonids, and lobsters • Systemic bacterial diseases—flounder and tilapia (NRSP-7) • Streptococcus—tilapia (SNARC)

  9. Nearing Completion—External antibacterials • Chloramine-T (IAFWA Project and sponsor) • Bacterial gill disease—all freshwater-reared salmonids (AADAP, UMESC) • External columnaris disease—walleye (UMESC)

  10. Nearing Completion—External antibacterials (continued) • Hydrogen peroxide (IAFWA Project) • Bacterial gill disease—all freshwater-reared salmonids (UMESC) • External columnaris disease—all coolwater fish & channel catfish (UMESC) • Oxytetracycline immersion (IAFWA Project & MCGP) • Bacterial gill disease—coolwater & warmwater fish (UMESC) • External columnaris disease—coolwater & warmwater fish (UMESC) • Systemic columnaris disease—coolwater & warmwater fish (UMESC)

  11. Work Underway or Possibility—External antibacterials (continued) • Copper sulfate (IAFWA Project) • Possibility for development (SNARC) • Potassium permanganate (IAFWA Project) • Possibility for development (SNARC) • Pyceze® (sponsor) • Early development stage

  12. Completed or Nearing Completion—Fungicides (control saprolegniasis) • Formalin—salmon, trout, & esocid eggs • Approval extended (IAFWA Project, UMESC)—all fish eggs 6/18/98 • Almost complete—all fish (UMESC) • Hydrogen peroxide (IAFWA Project) • Almost complete—all fish eggs (UMESC) • Almost complete—all fish (UMESC)

  13. Work Underway—Fungicides (control saprolegniasis) (continued) • Copper sulfate (IAFWA Project & sponsor) • Work underway (SNARC) • Potassium permanganate (IAFWA Project) • Possibility for development (SNARC) • Pyceze® (sponsor) • Work underway

  14. Completed or Nearing Completion—External parasiticides • Copper sulfate (IAFWA Project and sponsor) • Ichthyophthirius—channel catfish in earthen ponds (SNARC) • Formalin—Approvals for certain fish & penaeid shrimp—external protozoans • Approval extended (NRSP-7, IAFWA Project, &UMESC)—all fish—external protozoans & monogenetic trematodes 6/18/98 • Hydrogen peroxide (IAFWA Project) • External protozoans—salmonids (UMESC) • Sea lice controls • Slice®—Sponsor actively pursuing claim

  15. Work Underway—External parasiticides (continued) • Potassium permanganate (IAFWA Project) • Ichthyophthirius—channel catfish in earthen ponds (SNARC) • Pyceze® (sponsor) • Early development stage

  16. Work Underway—Internal Parasiticides • Myxozoan controls • Fumagillin • Whirling disease—trout (way underway by FWS, others) • Proliferative gill disease—catfish (some work by Mississippi State University) • Digenetic trematode or cestode controls • Praziquantel • Bolbophorus confusus in catfish (under consideration by sponsor)

  17. STATUS OF EFFORTS TOWARD APPROVALS—OTHER AQUACULTURE DRUGS

  18. Completed or Work Underway—Zero withdrawal Anesthetics • AQUI-S™ (IAFWA Project and sponsor)—major effort underway by both entities • All freshwater-reared fish (AADAP & UMESC) • Saltwater salmonids (sponsor & IAFWA Project) • MS-222 • Approved—several fish species but with 21-day withdrawal time

  19. Who Needs Zero Withdrawal Anesthetic? • All private fish & shellfish aquaculture industries • All federal & state agencies involved in: • Fish & shellfish culture • Commercial & recreational fisheries • Fisheries & stock restoration • Threatened & endangered aquatic species

  20. Completed or Work Underway—Spawning aids • Human chorionic gonadotropin (many partners) • Approved—all fish 9/7/99 • Crude carp pituitary (NRSP-7) • Almost complete but no possibility of product chemistry, so LRP? • Ovaplant™ & Ovaprim™ (sponsor) • Work underway • ReproBoost™ (sponsor) • Work underway

  21. Nearing Completion—Gender Manipulation Aids • 17 alpha-methyltestosterone (sponsor & Auburn University)—tilapia & other species • Contract let for product chemistry data • Contract let for environmental safety data • Contract to be let for target animal safety—tilapia

  22. Completed or Work Underway—Chemical Marking Aids • Calcein (have sponsor)—work underway • Oxytetracycline immersion (NRSP-7, various partners including IAFWA Project) • Approved—all fish 12/24/03 • Strontium chloride (have sponsor)—work underway through NRSP-7

  23. FUTURE PLANS

  24. Future Plans • Develop data on all drugs in progress for initial or supplemental NADAs; complete goals of the IAFWA Project • Seek additional sponsors for additional drugs to gain initial or supplemental NADAs • Seek additional funding sources for aquaculture drug approval research

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