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Western Blot Analysis of ERα in MCF-7 and ZR-75-1 Cells Treated with Hormonal Agents

This study investigates the expression levels and localization of ERα in MCF-7 and ZR-75-1 breast cancer cells under various treatments including OHT, ICI, and E2. Cytoplasmic and nuclear lysates were analyzed using Western blotting to assess the effects of these hormonal agents on ERα and tubulin expression. Supplementary Figure S2 presents the results, highlighting differences in receptor localization and potential implications for therapeutic strategies in estrogen receptor-positive breast cancer.

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Western Blot Analysis of ERα in MCF-7 and ZR-75-1 Cells Treated with Hormonal Agents

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  1. ZR-75-1+OHT MCF7 + OHT ZR-75-1+OHT MCF7 +OHT ZR-75-1 ZR-75-1 MCF7 MCF7 cyto nuc cyto nuc ERα Tubulin ZR-75-1+ICI ZR-75-1+ICI MCF7 + ICI MCF7 + ICI ZR-75-1 ZR-75-1 MCF7 MCF7 cytoplasmic nuclear ERα Tubulin ZR-75-1+E2 ZR-75-1+E2 MCF7 + E2 MCF7 + E2 ZR-75-1 ZR-75-1 MCF7 MCF7 cytoplasmic nuclear ERa tubulin Supplementary Figure S2. Nuclear and cytoplasmic lysates from MCF-7 and ZR-75-1 cells with or without OHT, ICI or E2 were analysed by western blotting. Millour et al Fig S2

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