Antibiotics. Mechanism of Action and Resistance. Antimicrobial Action and Resistance. Definition, concept of selective toxicity Targets and mechanisms of action of the major antibacterial agents Mechanisms of resistance to antibacterial agents Evolution and spread of antibiotic resistance.
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Mechanism of Action and Resistance
Cause misreading of mRNAProtein synthesis inhibitors (PSI): Aminoglycosides
Aminoglycosides, eg. Streptomycin, Gentamicin, Amikacin
NB. The only protein synthesis inhibitors that are bactericidal
Amphotericin B , Nystatin
Bind ergosterol disrupt cell membrane
Inhibit DNA & RNA
Inhibit microtubule assembly