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Innate Immunity & Inflammation. Dr. M. Izad Oct 2014. Objectives. Innate immunity Physical barriers Chemical barriers Cellular Barriers Connections between innate & adaptive immunity Inflammation. Innate & Adaptive Immunity. Mucus & Mechanical factors

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Presentation Transcript
objectives
Objectives
  • Innate immunity
    • Physical barriers
    • Chemical barriers
    • Cellular Barriers
  • Connections between innate & adaptive immunity
  • Inflammation
slide4

Mucus & Mechanical factors

  • Commensal flora (infection by Candida spp, Clastridiuumdifficile)
  • PH chenges (Production of glycogen by the epithelium in the vagina)
some antimicrobial peptides
Some antimicrobial peptides
  • Membrane disruption
  • Inhibiting the synthesis of DNA, RNA or proteins
  • Activating antimicrobial enzymes
  • Staphylococcus aureus
  • Streptococcus pneumoniae
  • E.Coli
  • Pseudomonas aeruginosa
  • Hemophilus influenzae
  • Fungi
  • Viruses
killing mechanism in leukocytes

Killing Mechanism in Leukocytes

Oxidative

Reactive Oxygen Species (ROS) (NADPH phagosomeoxidase/ Phox)

Reactive Nitrogen Species (RNS)

Non oxidative

Fusion of neutrophil granules with phagosomes

Antimicrobial peptides (defensins & cathelicidins) Antimicrobial proteins (BPI: bactericidal/ permeability increasing protein)

Enzymes (proteases & lysozyme)

slide22

TLR

Bacteria

Fungi

protozoa

dendritic cells dc

Dendritic cells (DC)

As agents of innate immunity, immature dendritic cells use a variety of PRRs (TLRs) to recognize pathogens.

Provide a link between innate & adaptive immunity.

Are able to generate ROS, NO & antimicrobial peptides.

Plasmacytoid DCs are potent producers of type I interferons.

inflammation acute chronic
Inflammation Acute/Chronic

Inflammation is a physiological response to a variaty of stimuli such as infections and tissue injury.

hallmarks of inflammation
Hallmarks of Inflammation
  • Increasing of vascular permeability
    • Swelling (edema)
  • vasodilation
    • Redness
    • Heat
  • extravasation
  • Pain
  • Loss of function
recruitment of macrophages antimicrobial agents from the bloodstream in an inflammation response
Recruitment of macrophages & antimicrobial agents from the bloodstream in an inflammation response
chronic inflammation develops when antigen persists

Chronic Inflammation develops when Antigen persists

the accumulation & activation of macrophages is the hallmark of chronic inflammation.

Fibrosis

Granuloma (giant cells, epitheloid cells)

slide43
Quiz
  • …….یکپروتئینضدمیکروبیاستکهبرایتشخیصبیماریهایالتهابیرودهبهکارگرفتهمیشود.
  • ………آنزیمیاستدرغشاءسلولهایفاگوسیتکهشروعکنندهتولید…………است.