Innate Immunity & Inflammation. Dr. M. Izad Oct 2014. Objectives. Innate immunity Physical barriers Chemical barriers Cellular Barriers Connections between innate & adaptive immunity Inflammation. Innate & Adaptive Immunity. Mucus & Mechanical factors
Dr. M. Izad
Fig. 4-3 B
Reactive Oxygen Species (ROS) (NADPH phagosomeoxidase/ Phox)
Reactive Nitrogen Species (RNS)
Fusion of neutrophil granules with phagosomes
Antimicrobial peptides (defensins & cathelicidins) Antimicrobial proteins (BPI: bactericidal/ permeability increasing protein)
Enzymes (proteases & lysozyme)
Fig. 4-8 A
Fig. 4-8 B
As agents of innate immunity, immature dendritic cells use a variety of PRRs (TLRs) to recognize pathogens.
Provide a link between innate & adaptive immunity.
Are able to generate ROS, NO & antimicrobial peptides.
Plasmacytoid DCs are potent producers of type I interferons.
Inflammation is a physiological response to a variaty of stimuli such as infections and tissue injury.
the accumulation & activation of macrophages is the hallmark of chronic inflammation.
Granuloma (giant cells, epitheloid cells)