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Alterations in Gene Expression in Treated Fish: Insights from 3-Methylcholanthrene Study

This study investigates the changes in gene expression in fish treated with 3-Methylcholanthrene (3-MC) following an IP injection of 25 mg/kg. We observed a 10-fold increase and decrease in gene expression levels at 1-day, analyzed by applying the Benjamini & Hochberg multiple testing correction (P < 0.05). Using scatter plots, we identified specific genes and pathways altered in the treated groups compared to controls, highlighting significant 2-fold induction at day 1. The findings could provide insights into the molecular mechanisms of chemical exposure.

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Alterations in Gene Expression in Treated Fish: Insights from 3-Methylcholanthrene Study

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  1. Treated fish show many changes in gene expression Which genes and which pathways are altered?? 10 fold up 1:1 10 fold down Day after IP injection 1 2 4 8 16 1 2 4 8 16 3-MC 25mg/kg Carrier Controls Clones 2-fold induced at day1 3-MC Benjamini & Hochberg MTC, P<0.05 Scatter plot 3MC day 1 Scatter plot control day1

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