Template HTA General Assembly November 12 – 13, 2013. Martin Richter, Fraunhofer EMFT. Project Idea: Tumor therapy EU call: PHC 12 - 2014) New therapies for chronic non-communicable diseases.
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HTA General Assembly
November 12 – 13, 2013
Project Idea short description:Development of a drug delivery system for tumor therapy, which can deliver small amount high concentrated cytostatica directly into the tumor tissue
Short Description:the system can deliver volumes of 15 µl of drugs with an accuracy of better 3%. The flow would be monitored by capacitive sensors. Silion micropumps with a stroke volume of 80 nl drive the drug. A integrated safety valve avoids free flow. Safety electrode can detect pump failure, valve leakage, air bubbles. The system is running stand alone for 4 weeks, the dosing profile can be changed remote controlled by the medical doctor.
IP situation and commercial viability: Fraunhofer EMFT holds several strong patents in the field of micropumps and micro valves technologies. Furthermore, a patent for the microdosing concept has ben submitted. A Fraunhofer alliance has already built up first demonstrators.
Potential Applications / Applications:Therapy of (up to now) inoperable tumor tissues in the final state of a tumor desease. Furthermore, the drug dosing system can be used in other applications like pain therapy, therapy of diabetes, hormone therapy. The system can be mounted outside the body with a canuelae or as a short time implant (4 weeks).
Potential Consortium/Competences needed: Company 1: medical device company; company 2: pharmaceutical company; company 3: MEMS fab; company 4 (or institute): electronic development
Dosing unit with micropumps
Tumor therapy: challenges
Micro dosing with micropumps
Small dead volumes: near to tumor, implanted
Dosing profile to be controlled by doctor:
system control, control unit
Micro dosing for cancer treatment
Detection on meniscus movement
Used for cycle control