ANNOUNCEMENTS: Proposal first drafts are due Thursday, 11/12. You may turn it in as late as 11/19, without penalty, however, drafts received after 11/13 may not be reviewed prior to the Thanksgiving break.
Primary Papers for this week Riddle, Johnson, Laufer, and Tabin (1993). Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75:1401-1416. Litingtung, Dahn, Li, Fallon, and Chiang (2002). Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity. Nature 418:979-983.
Primary Papers for next week • Demir and Dickson (2005) fruitless Splicing Specifies Male Courtship Behavior in Drosophila . Cell 121:785-794. • Vrontou, Nilsen, Demir, Kravitz &Dickson (2006). fruitless regulates aggression and dominance in Drosophila. Nature Neuroscience 9:1469-1471.
Chapter 13 Neural crest cells and axonal specificity
Dorsal Spinal cord Fibroblasts (no cue) Fibroblasts Netrin-1 Floor Plate
Figure 8. A Model for UNC5–DCC Interactions (A) In the absence of UNC5 proteins, netrin-1 causes a change (perhaps conformational) in DCC that results in the recruitment of some adaptor proteins (Y and Z) but not others (W). A “coreceptor for attraction” (“X?”) may be recruited and necessary as well (see text). (B) In the presence of UNC5 proteins, changes (perhaps conformational) in both the UNC5 and DCC proteins result in the interaction of their cytoplasmic domains and consequently the recruitment of a different complement of adaptors (Y and W, not Z). It may also involve exclusion of a putative coreceptor for attraction. The diagram is drawn as if the DB and P1 domains interact directly, but this has not been shown.
Chapter 16 Vertebrate Limb Development