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Mef2c deletion in osteocytes results in increased bone mass

Mef2c deletion in osteocytes results in increased bone mass. Osteoscoop - Issue N°237 – May 2012. Mef2c. Osteocyte. Sost. Sclerostin. Preosteoblasts. Osteoblasts. Mef2c. Osteocyte. -40%. Sost. Sclerostin. Preosteoblasts. -40%. Osteoblasts. No effect on bone formation. Mef2c.

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Mef2c deletion in osteocytes results in increased bone mass

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  1. Mef2c deletion in osteocytes results in increased bone mass Osteoscoop - Issue N°237 – May 2012

  2. Mef2c Osteocyte Sost Sclerostin Preosteoblasts Osteoblasts

  3. Mef2c Osteocyte -40% Sost Sclerostin Preosteoblasts -40% Osteoblasts No effect on bone formation

  4. Mef2c Endosteal sinus Osteocyte OPG Monocytes -40% Preosteoclasts Sost Osteoclast Sclerostin Preosteoblasts -40% Low bone resorption activity +70% Osteoblasts No effect on bone formation

  5. Mef2c Endosteal sinus Osteocyte OPG Monocytes -40% Preosteoclasts Sost Osteoclast Sclerostin Preosteoblasts -40% Low bone resorption activity +70% Osteoblasts Increased bone mass No effect on bone formation

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