Mitochondrial Oxidative Phosphorilation and Genetics. Abigail Hardy. The Mitochondria. Thousands of mitochondria in high energy areas Contact sites facilitate the entry of protiens into matrix Produces ~90% of the cellular ATP in eukaryotic cells. Major Protien Complexes.
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
Complexes I to IV, in addition to other components, act together as an electron transport chain
Protons in intermembrane space form an electrochemical gradient, which provides potential energy used by complex V for the phosphorylation of ADP to ATP.
Membrane channel protien (ANT) transports ATP out and ADP into matrix
1:1 ratio of transfer
Both ADP and ATP move freely through the outer membraneOxidative Phosphorylation
Mitochondria have their own genetic apparatus together as an electron transport chain
Circular (16,568 bp)
2-10 separate mitochondrial gemomes in matrix
Carries information for:
The 13 proteins encoded are involved in OXPHOS functions
Nuclear genes encode about 70 additional protiens that make up the OXPHOS system
A mitochondrion is the joint product of two different genetic systemsMitochondrial DNA
Human oocyte loses mitochondria as it matures through the genetic bottleneck
Mitochondria are randomly distributed into daughter cells
Mitochondrial Mutation Load= the ratio of mutated to normal mitochondrial DNA
Homoplasmy= all mitochondria of a cell or tissue have the same genome
Heteroplasmy= contains both mutant and wild-type genomes
Proportion of mutant to wild-type M. DNA determines if energy shortage occurs
Threshold for phenotypic expressionOocyte Mitochondria