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Mechanisms of Growth Factors in Regulating Mitochondrial Apoptosis and Cancer Treatment Resistance

This article explores the role of various growth factors and signaling pathways in regulating apoptosis, particularly in the context of cancer treatments. Key elements such as the Fas receptor, Akt, PKC, and caspases (like Caspase 3, 8, 9, and 12) are discussed in relation to their impact on mitochondrial functions and apoptotic signaling. The interaction of oncogenic signals, DNA damage, and ER stress responses in modulating gene expression and apoptotic pathways is also analyzed, providing insights into potential therapeutic strategies to enhance cancer treatment efficacy.

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Mechanisms of Growth Factors in Regulating Mitochondrial Apoptosis and Cancer Treatment Resistance

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  1. Growth Factors Fas Growth Factor Receptor Akt PKC PI3K p90RSK Procaspase8 Caspase3 Caspase9 Caspase12 BAD FasL VDAC tBID BAX BAK BID CIAP1 SMAC PMR BCL2 ANT Arts BIM p53AIP1 HTRA2 FADD APAF1 BCLXL CytoC PUMA Noxa CypD AIF AIF EndoG EndoG p14ARF MDM2 2009 ProteinLounge.com p53 p53 ATM Chk2 C Withdrawl of Growth Factors Chemothera-peutic Drugs Mitochondrial Apoptosis Caspase8 MMP APOPTOSIS Depolarization Oncogenic Signal DNA Fragmentation ER Stress Gene Expression DNA Damage

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