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Bupprenorphine Glucuronide to Norbuprenorphine Glucuronide Ratio

1. 2. A. 1.5. 1. 0.5. 0.5. 0. 0. 1. 2. B. 1.5. 0.5. 1. 0.5. 0. 0. 2. C. 1. 1.5. 1. 0.5. 0.5. 0. 0. A. B. C. D. E. F. G. H. I. A. B. C. D. E. F. G. H. I. Participant. Participant. Norbuprenorphine to Norbuprenorphine Glucuroide Ratio.

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Bupprenorphine Glucuronide to Norbuprenorphine Glucuronide Ratio

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  1. 1 2 A 1.5 1 0.5 0.5 0 0 1 2 B 1.5 0.5 1 0.5 0 0 2 C 1 1.5 1 0.5 0.5 0 0 A B C D E F G H I A B C D E F G H I Participant Participant Norbuprenorphine to Norbuprenorphine Glucuroide Ratio Bupprenorphine Glucuronide to Norbuprenorphine Glucuronide Ratio Supplemental Figure 1: Buprenorphine glucuronide (BUP-Gluc) to norbuprenorphine glucuronide (NBUP-Gluc) (Left) and norbuprenorphine (NBUP) to NBUP-Gluf (Right) ratios for nine participants during the A) second trimester, B) third-trimester and C) post-partum. At p<0.05 the following statistically significant differences were identified: For BUP-Gluc to NBUP-Gluc, participants A and G: 3rd trimester>post-partum; participants C and D: 2nd trimester<3rd trimester, participant B: 2nd<PP; participant H: 3rd<PP. For NBUP to NBUP-Gluc, participant E: 2nd trimester<3rd trimester and 3rd trimester<PP; participant H: 2nd and 3rd trimester<PP

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