Comparative Effectiveness Research: Now and in the Future. Children’s Hospital of Philadelphia July 13, 2009 Patrick Conway, MD, MSCE Chief Medical Officer, OS/ASPE Department of Health and Human Services. Disclosure. I am an employee of federal government
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Children’s Hospital of Philadelphia
July 13, 2009
Patrick Conway, MD, MSCE
Chief Medical Officer, OS/ASPE
Department of Health and Human Services
Comparative effectiveness research is the conduct and synthesis of research comparing the benefits and harms of different interventions and strategies to prevent, diagnose, treat and monitor health conditions in “real world” settings. The purpose of this research is to improve health outcomes by developing and disseminating evidence-based information to patients, clinicians, and other decision-makers, responding to their expressed needs, about which interventions are most effective for which patients under specific circumstances.
The criteria for scientifically meritorious research and investments are:
Human & Scientific Capital Legislation
Dissemination and TranslationFCC Report: Strategic Framework for CER
Cross- Cutting Priority Themes
Types of Interventions
Investments can be made in a single category and/or be cross-cutting in one of the themes
Four major categories:
Types of Interventions
Dissemination and Translation Legislation
Types of InterventionsCouncil’s Recommended OS Investment Strategy
Human & Scientific Capital
Crosscutting Priority Themes
- to prepare a list of priorities for research funding and recommendations to implement a sustained CER effort
“CER is the generation and synthesis of evidence that compares the benefits and harms of alternative methods to prevent, diagnose, treat, and monitor a clinical condition or to improve the delivery of care. The purpose of CER is to assist consumers, clinicians, purchasers, and policy makers to make informed decisions that will improve health care at both the individual and population levels.”
Recommended Legislation100 priority CER topics and research questions divided into four quartiles
Compare the effectiveness of treatment strategies for atrial fibrillation
Compare the effectiveness of comprehensive care coordination programs, such as the medical home model
Compare the effectiveness of various screening, prophylaxis and treatment interventions in eradicating methicillin resistant staph aureus
1 Conway PH, Clancy C. Comparative Effectiveness Research – Implications
of the Federal Coordinating Council’s Report. N Engl J Med 2009 June 30.
2 Iglehart R. Prioritizing Comparative Effectiveness Research – IOM Recommendations.
N Engl J Med 2009 June 30.
1 Dougherty D, Conway PH. The T3 Roadmap to Transform U.S. Health Care:
The How of High Quality Care. JAMA. 2008 May 21; 299(19): 2319-21.
2 Conway, PH, Clancy C. Transformation of Health Care at the Frontline. JAMA. 2009 Feb 18;301(7):763-5.