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Effects of Bilateral Kainate Injection on Seizure Duration in GAERS

This study investigates the impact of bilateral kainate injection into the parafascicular nucleus on seizure duration in Genetic Absence Epilepsy Rats from Strasbourg (GAERS). Results show significant changes compared to saline injection. Injection sites reconstructed in the parafascicular nucleus are shown on a modified coronal brain section.

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Effects of Bilateral Kainate Injection on Seizure Duration in GAERS

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  1. A B CumulatedSWD duration/20 min (s) 600 400 * 200 0 AP:- 4.16 mm Time (min) Ref 0-20 20-40 40-60 Figure 2: A. Effects of bilateral injection of kainate (35 pmol/side; black squares) into the parafascicular nucleus on mean ± SEM cumulated duration of SWD in GAERS (n=8) *: P< 0.05 as compared to saline (open diamonds), ANOVA. B. Reconstruction of the injection sites in the parafascicular nucleus on an identified coronal section modified from the atlas of Paxinos and Watson. PF : n. parafascicularis; VPM : ventropostero medial nucleus of the thalamus.

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