1 / 7

Duodenum, liver and Pancreas

Duodenum, liver and Pancreas. Prof. K. Sivapalan. Duodenum. Pancreas and liver develop from intestinal epithelium. The pancreatic duct and bile duct open into duodenum by common passage, Ampula of Vater, via sphinter of Oddi Duodenum secrets several hormons Mucus glands- HCO 3 production.

kenny
Download Presentation

Duodenum, liver and Pancreas

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Duodenum, liver and Pancreas Prof. K. Sivapalan.

  2. Duodenum • Pancreas and liver develop from intestinal epithelium. • The pancreatic duct and bile duct open into duodenum by common passage, Ampula of Vater, via sphinter of Oddi • Duodenum secrets several hormons • Mucus glands- HCO3 production Duodenum, Liver and Pancreas

  3. Secretine • It is the first hormone identified by Bayliss and Starling, [students] • Secreted by S cells in duodenal mucosa. • Stimulus- acid, products of protein digestion. • Effects- • bicarbonate [watery alkaline] secretion from pancreas and biliary tract. • Inhibits acid secretion from stomach Duodenum, Liver and Pancreas

  4. Cholecystokinin [CCK-PZ]. • Stimulus: • Fatty acids with more than 10 Carbon. • Digestive products of protein. • Effects: • Contraction of gallbladder • Secretion of pancreatic juice rich in enzyme. • Inhibits gastric emptying. • Positive feed back: effects increase stimuli Duodenum, Liver and Pancreas

  5. Pancreas • Pancreatic juice: pH- 8, 1500 ml/day. • Enzymes: • Trypsinogen, chymotrypsinogen, procarboxyl peptidases, lipase, amylase, ribonuclease, deoxyribonuclease, phospholipase, etc. • Enterokinase converts Trypsinogen into active Trypsin which activates all other enzymes. • In pancreas, a trypsin inhibitor prevents accidental activation of trypsin. • If it fails acute pancreatitis can cause death by digestion of abdominal contents. • Control- CCK, Secretin, Vagus[mild] Duodenum, Liver and Pancreas

  6. Secretion bile salts: synthesis, entero- hepatic circulation. cholesterol and other lipids. plasma proteins- clotting factors and albumin. Excretion of insoluble wastes by conjugation with glucuronic acid. bile pigments [golden yellow] Inactivation of hormones Activation of hormones Metabolism: Carbohydrate, protein, fat Detoxification toxins and drugs Intestinal toxins, amonia Storage: Carbohydrate Protein Vitamins Protection- Kupffer cells Liver Functions. Duodenum, Liver and Pancreas

  7. Bile • 500 ml per day. • Stored and concentrated in gallbladder. • Continuous flow is prevented by Sphincter of Boyden, found before joining with pancreatic duct in ampula of Vater. both open through sphincter of Oddi. • Gallstones: calcium bilirubinate or cholesterol. • Can block bile duct and cause obstructive Jaundice Duodenum, Liver and Pancreas

More Related