Smallpox vaccine in combination with ST-246. Robert Jordan, Ph.D. SIGA Technologies, Inc. FDA – Public Hearing May 17, 2007. Sentinel Case. Exposure. Rash……………Death. Fever. Incubation. ~ 14 days. ~ 21 days. ~ 3 days. ACAM-2000. MVA. ST-246. Golden Hours. ST-246.
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Robert Jordan, Ph.D.
SIGA Technologies, Inc
FDA – Public Hearing May 17, 2007
orthopoxvirus induced pathogenesis and/or disease
primate model of orthopoxvirus disease
treatment of smallpox approved
ST-246Target is F13L
*Animals infected in presence of ST-246 develop a protective immune response