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CDC Smallpox Vaccine Production . ACIP May 8, 2002 . Smallpox Vaccine Products. Overview . Wyeth Dryvax (1:1 & 1:5) Acambis Vaccinia Vaccine in MRC5 Cells (Acam1000) Acambis Vaccinia Vaccine in Vero Cells (Acam2000) Aventis Pasteur Vaccine. ~54 million doses . Acam 1000.

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smallpox vaccine products
Smallpox Vaccine Products

Overview

  • Wyeth Dryvax (1:1 & 1:5)
  • Acambis Vaccinia Vaccine in MRC5 Cells (Acam1000)
  • Acambis Vaccinia Vaccine in Vero Cells (Acam2000)
  • Aventis Pasteur Vaccine
slide3

~54 million doses

Acam 1000

~155 million doses

Acam 2000

Dryvax

AvP Vaccine

15 million doses – undiluted

75 million @ 1:5 dilution

70-90 million doses

Smallpox Vaccine Supply and Production

2001

2002

2003

2004

2005

1983

smallpox vaccine related supplies
Smallpox Vaccine Related Supplies

Overview

Provides for:

  • Bifurcated Needles
    • 15 million for original Dryvax stock
    • 60 million for 1:5 dilution Dryvax supplies
  • Diluent for 1:5 Dryvax
  • Protocols
  • Storage & Distribution
  • VIG
acam1000 phase i clinical trial

group

group

# of subjects

# of subjects

vaccination

vaccination

completion

completion

1

20

5-Mar-02

19-Apr-02

2

16

13-Mar-02

27-Apr-02

3

24

26-Mar-02

10-May-02

Acam1000 Phase I Clinical Trial
smallpox vaccine production
SMALLPOX VACCINE PRODUCTION

Summary

  • Vaccine for “All Americans” by end of 2002
  • All vaccines now under IND
  • Clinical trials through Phase 2 done by end of 2002; licensure late 2003 or 2004
  • Production includes bifurcated needles, dil.
  • VIG contract under negotiations now
  • NPS storage site for rapid deployment