LUSH PHEROMONE. Manhasset Science Research Jillian Wong. NEED. 2006- 881,000 people died from malaria 91% of those were children in Africa, and here was an estimated 247 million cases globally. http://www.cdc.gov/Features/dsMalariaSurveillance/. NEED.
Manhasset Science Research
Structure of ethanol
The Lush protein is needed in the detection, discrimination, and perception of volatile odors
Figure 2: X-ray Crystal Structure of LUSH-cVA complex. The VA is completely enveloped within the protein. http://www.uccc.info/for-healthcare-professional/cancer-center/cores/structural-biology/structural-biology.aspx
Fig. 1. a Surface representation of key residues in the LUSH alcohol-binding pocket. The pocket is lined with hydrophobic residues with the exception of Thr57 and Ser52, which form concerted hydrogen bonds with the alcohol. Ethanol is shown in a stick representation. The hydrogen bonds between the alscohol and the hydroxyl groups of Thr57 and Ser52 are shown as yellow dotted lines.
(A) Schematic of the Drosophila olfactory system. The distal tip of the third antennal segment is densely covered with olfactory sensilla (inset 1). Transverse section through a T1 trichoid sensillum. OSN, olfactory sensory neuron; L, sensillum lymph; OR, odorant receptor; OBP, odorantbinding protein (inset 2).
B) Electrophysiological recordings from T1 OSNs in wild-type flies show responses to the pheromone 11-cis vaccenyl acetate that are absent
in lush mutants. Mutant flies also show a drastic decrease (400-fold) in spontaneous spiking activity.