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Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CRK5 Structural Gene

Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CRK5 Structural Gene. Yenny Sanchez. A rticle that we have been analyzing in class for a better understanding of Dean’s research. Interpretation of figure 2 and table 2.

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Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CRK5 Structural Gene

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  1. Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CRK5 Structural Gene Yenny Sanchez

  2. Article that we have been analyzing in class for a better understanding of Dean’s research. • Interpretation of figure 2 and table 2.

  3. Figure 2 is a graph that shows a genotype frequency test. • The G test as explained in the reference section of the paper (39) “is a likehood ratio that is equivalent to the x2 test but less sensitive to very low expected values”. • This test was done to determine thru the use of 170 loci, the association between HIV-1 positive versus HIV-1 negative individuals

  4. Fig. 2 Genotypic markers and HIV-1 infection.

  5. None of the loci tested shows a distortion between the two different samples, negative versus positive HIV-1 individuals. • As seen figure # 2, CKR5 has a big peak showing that it is highly active. • Dean shows the genotypic markers and HIV -1 infection. • From this Dean was able to get to the conclusion that the absence of the loci shows no effect to the genes generally close to the markers.

  6. Table #2 shows the association and genotype distribution between HIV-1 positive and HIV-1 negative individuals. • They found 17 homozygotes for CKR5 among the people that were tested. • It was highly related with individuals that were HIV-1 negative and had a big risk of the disease.

  7. The association of the 32/32 genotype was as follows (G = 35.0 P = 2.5 × 108; Table 2) for the HIV-1 negative individuals. • Other 3 individual cohorts were also related and those were MACS, SFCC, and MHCS. • The CKR532 allele is a recessive phenotype and is associated with HIV-1 infection, antibody production and its resistance.

  8. Reference • Dean, M. et al., 1996. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science 273:1856-1862.

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