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Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CRK5 Structural Gene PowerPoint Presentation
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Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CRK5 Structural Gene. Yenny Sanchez. A rticle that we have been analyzing in class for a better understanding of Dean’s research. Interpretation of figure 2 and table 2.

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slide1

Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CRK5 Structural Gene

Yenny Sanchez

slide2
Article that we have been analyzing in class for a better understanding of Dean’s research.
  • Interpretation of figure 2 and table 2.
slide3
Figure 2 is a graph that shows a genotype frequency test.
  • The G test as explained in the reference section of the paper (39) “is a likehood ratio that is equivalent to the x2 test but less sensitive to very low expected values”.
  • This test was done to determine thru the use of 170 loci, the association between HIV-1 positive versus HIV-1 negative individuals
slide5
None of the loci tested shows a distortion between the two different samples, negative versus positive HIV-1 individuals.
  • As seen figure # 2, CKR5 has a big peak showing that it is highly active.
  • Dean shows the genotypic markers and HIV -1 infection.
  • From this Dean was able to get to the conclusion that the absence of the loci shows no effect to the genes generally close to the markers.
slide7
Table #2 shows the association and genotype distribution between HIV-1 positive and HIV-1 negative individuals.
  • They found 17 homozygotes for CKR5 among the people that were tested.
  • It was highly related with individuals that were HIV-1 negative and had a big risk of the disease.
slide8
The association of the 32/32 genotype was as follows (G = 35.0 P = 2.5 × 108; Table 2) for the HIV-1 negative individuals.
  • Other 3 individual cohorts were also related and those were MACS, SFCC, and MHCS.
  • The CKR532 allele is a recessive phenotype and is associated with HIV-1 infection, antibody production and its resistance.
reference
Reference
  • Dean, M. et al., 1996. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science 273:1856-1862.