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Myasthenia Gravis Symptoms, Causes, Treatments, Prognosis, Cure, and Life Expectancy By Kim Anderson
What is the medical definition of myasthenia gravis? • Myasthenia gravis is a chronic autoimmune neuromuscular disease characterized by varying degrees of weakness of the skeletal (voluntary) muscles of the body. • The thymus may give incorrect instructions to developing immune cells, ultimately resulting in autoimmunity and the production of the acetylcholine receptor antibodies.
What symptoms would you expect from myasthenia gravis? • Symptoms and signs of myasthenia gravis may include: • Problems with vision, called ocular myasthenia gravis and include: • Eye muscle weakness • Eyelid drooping (ptosis) • Blurry or double vision (diplopia) • Problems walking • Changes in facial expressions • Problems swallowing • Shortness of breath • Problems speaking • Weakness in the arms, hands, fingers, legs, and neck
What is the cause of myasthenia gravis? • Myasthenia gravis is caused by a defect in the transmission of nerve impulses to muscles. • Myasthenia gravis is not directly inherited nor is it contagious. • Commonly, the disease affects adult women (under 40) and older men (over 60), but it can occur at any age. • Diagnosis of myasthenia gravis often is delayed because muscle weakness is a common symptom other diseases and conditions and may slowly develop.
How do you test for myasthenia gravis • Tests to diagnose myasthenia gravis is diagnosed with tests that help confirm the diagnosis include: • Detecting the presence of immune molecules or acetylcholine receptor antibodies • Edrophonium test • Electromyography • Myasthenia gravis is treated with medications, for example: • The drug Soliris is approved for adult patients with generalized Myasthenia Gravis (gMG) who are anti-AchR antibody-positive. • Anticholinesterase agents (for example, neotigmine) • Plasmapheresis • Various immunosuppressive drugs • Surgical treatment may include removal of the thymus. • A myasthenic crisis occurs when the muscles that control breathing weaken so much that you need emergency ventilation assistance to help breath.
Is myasthenia gravis life threatening? • The disease prognosis and life expectancy is highly variable. Some people have complete remission (about 50% with thymus surgery) others have relatively normal lives with continued treatment, and others have a poor prognosis as the disease advances. • Research is ongoing for myasthenia gravis. New treatment protocols and immunosuppressive drugs are being tried, and therapeutic methods are likely to improve in the future.
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