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REGULACE TVORBY ERYTROPOETINU. Denisa Chadimová, 9.kruh 2011/2012. ERYTROPOETIN. Vztah Hb , erytropoetinu a erytropoezy. NEDOSTATEK EPO. DOSTATEK EPO. Transportní kapacita kyslíku. Hb. Počet erytrocytů. =. =. =. H Y P O XIE. HYPOXIE. Peritubulární buňka kortexu ledvin.

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regulace tvorby erytropoetinu

REGULACE TVORBY ERYTROPOETINU

Denisa Chadimová, 9.kruh 2011/2012

vztah hb erytropoetinu a erytropoezy
Vztah Hb, erytropoetinu a erytropoezy

NEDOSTATEK EPO

DOSTATEK EPO

Transportní kapacita kyslíku

Hb

Počet erytrocytů

=

=

=

HYPOXIE

hypoxie
HYPOXIE

Peritubulární buňka kortexu ledvin

HIF-1α–transkripční faktor indukovaný hypoxií (hypoxia-induciblefactor 1, alphasubunit)

HIF-1β- aryl hydrocarbon receptor nucleartranslocator

P300/CBP – komponenty transkripčního komplexu

HRE – responzivní element (hypoxia – responsive element)

HRE

TRANSKRIPCE GENU

ERYTROPOETIN

normoxie
NORMOXIE

VHL – vonHippel-Lindau

PHD – HIF-prolyl-hydroxykázy

Ub - Ubiquitin

oxidace

Peritubulární buňka kortexu ledvin

Ubikvitinizace

degradace

proteazom

zdroje
ZDROJE
  • http://en.wikipedia.org/wiki/Hypoxia_inducible_factors
  • http://www.wikiskripta.eu/index.php/Erytropoetin
  • http://www.remedia.cz/Clanky/Prehledy-nazory-diskuse/Molekularni-farmakologie-latek-stimulujicich-erytropoezu/6-F-iw.magarticle.aspx